Description: Homo sapiens GINS complex subunit 4 (Sld5 homolog) (GINS4), mRNA. RefSeq Summary (NM_032336): The yeast heterotetrameric GINS complex is made up of Sld5, Psf1 (GINS1; MIM 610608), Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]). See GINS1 for additional information about the GINS complex.[supplied by OMIM, Mar 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Transcript (Including UTRs) Position: hg19 chr8:41,386,725-41,402,565 Size: 15,841 Total Exon Count: 8 Strand: + Coding Region Position: hg19 chr8:41,387,722-41,399,606 Size: 11,885 Coding Exon Count: 7
ID:SLD5_HUMAN DESCRIPTION: RecName: Full=DNA replication complex GINS protein SLD5; AltName: Full=GINS complex subunit 4; FUNCTION: The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS4 is important for GINS complex assembly. GINS complex seems to bind preferentially to single-stranded DNA. SUBUNIT: Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS1. GINS complex interacts with DNA primase in vitro. SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). INDUCTION: Significantly up-regulated in agressive melanomas. MASS SPECTROMETRY: Mass=98373; Mass_error=13; Method=Electrospray; Range=1-223; Note=This is the measured mass for the GINS complex; Source=PubMed:17557111; SIMILARITY: Belongs to the GINS4/SLD5 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BRT9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0043138 3'-5' DNA helicase activity
Biological Process: GO:0000727 double-strand break repair via break-induced replication GO:0001833 inner cell mass cell proliferation GO:0006260 DNA replication GO:0006261 DNA-dependent DNA replication GO:0006270 DNA replication initiation GO:0006271 DNA strand elongation involved in DNA replication GO:0032508 DNA duplex unwinding
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