Human Gene SAP30BP (uc002jpe.3)
  Description: Homo sapiens SAP30 binding protein (SAP30BP), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr17:73,663,399-73,704,139 Size: 40,741 Total Exon Count: 11 Strand: +
Coding Region
   Position: hg19 chr17:73,663,453-73,702,601 Size: 39,149 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:73,663,399-73,704,139)mRNA (may differ from genome)Protein (308 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedReactomeTreefamUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: S30BP_HUMAN
DESCRIPTION: RecName: Full=SAP30-binding protein; AltName: Full=Transcriptional regulator protein HCNGP;
FUNCTION: Induces cell death. May act as a transcriptional corepressor of a gene related to cell survival. May be involved in the regulation of beta-2-microglobulin genes.
SUBUNIT: Interacts with SAP30.
INTERACTION: Q9UHX1:PUF60; NbExp=4; IntAct=EBI-751683, EBI-1053259;
SUBCELLULAR LOCATION: Nucleus.
INDUCTION: In fibroblasts by binding of HSV1.
SIMILARITY: Belongs to the HCNGP family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): SAP30BP
CDC HuGE Published Literature: SAP30BP

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 23.24 RPKM in Nerve - Tibial
Total median expression: 686.62 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -11.1054-0.206 Picture PostScript Text
3' UTR -645.921538-0.420 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012479 - HCNGP

Pfam Domains:
PF07818 - HCNGP-like protein

ModBase Predicted Comparative 3D Structure on Q9UHR5
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserGenome BrowserNo ortholog
Gene Details  Gene DetailsGene Details 
Gene Sorter  Gene SorterGene Sorter 
  EnsemblFlyBaseWormBase 
  Protein SequenceProtein SequenceProtein Sequence 
  AlignmentAlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006915 apoptotic process
GO:0010942 positive regulation of cell death

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0045111 intermediate filament cytoskeleton


-  Descriptions from all associated GenBank mRNAs
  AF450482 - Homo sapiens cell-line KMB-17 transcription-regulating protein (HTRG) mRNA, complete cds.
AK095265 - Homo sapiens cDNA FLJ37946 fis, clone CTONG2008792, highly similar to TRANSCRIPTIONAL REGULATOR PROTEIN HCNGP.
AK298060 - Homo sapiens cDNA FLJ53632 complete cds, highly similar to SAP30-binding protein.
BC030233 - Homo sapiens SAP30 binding protein, mRNA (cDNA clone MGC:34254 IMAGE:5229398), complete cds.
AY082382 - Homo sapiens HCNGP mRNA, complete cds.
BC007592 - Homo sapiens SAP30 binding protein, mRNA (cDNA clone MGC:15645 IMAGE:3346233), complete cds.
AF119664 - Homo sapiens transcriptional regulator protein HCNGP mRNA, complete cds.
BC063793 - Homo sapiens SAP30 binding protein, mRNA (cDNA clone MGC:70553 IMAGE:6502502), complete cds.
AK310177 - Homo sapiens cDNA, FLJ17219.
AK002202 - Homo sapiens cDNA FLJ11340 fis, clone PLACE1010771, highly similar to SAP30-binding protein.
BC011724 - Homo sapiens SAP30 binding protein, mRNA (cDNA clone IMAGE:4139101).
AB464187 - Synthetic construct DNA, clone: pF1KB8145, Homo sapiens SAP30BP gene for SAP30 binding protein, without stop codon, in Flexi system.
EU446793 - Synthetic construct Homo sapiens clone IMAGE:100069859; IMAGE:100012002; FLH258597.01L SAP30 binding protein (SAP30BP) gene, encodes complete protein.
CU675719 - Synthetic construct Homo sapiens gateway clone IMAGE:100018819 5' read SAP30BP mRNA.
KJ893688 - Synthetic construct Homo sapiens clone ccsbBroadEn_03082 SAP30BP gene, encodes complete protein.
AF087869 - Homo sapiens HCNGP mRNA, complete cds.
BC013409 - Homo sapiens SAP30 binding protein, mRNA (cDNA clone IMAGE:3028192), partial cds.
AK023157 - Homo sapiens cDNA FLJ13095 fis, clone NT2RP3002165, highly similar to TRANSCRIPTIONAL REGULATOR PROTEIN HCNGP.
LF209422 - JP 2014500723-A/16925: Polycomb-Associated Non-Coding RNAs.
BX647066 - Homo sapiens mRNA; cDNA DKFZp779J2016 (from clone DKFZp779J2016).
AK098247 - Homo sapiens cDNA FLJ40928 fis, clone UTERU2006643.
AL049465 - Homo sapiens mRNA; cDNA DKFZp586L2022 (from clone DKFZp586L2022).
JD380673 - Sequence 361697 from Patent EP1572962.
JD263585 - Sequence 244609 from Patent EP1572962.
JD269476 - Sequence 250500 from Patent EP1572962.
JD382810 - Sequence 363834 from Patent EP1572962.
JD354985 - Sequence 336009 from Patent EP1572962.
JD539375 - Sequence 520399 from Patent EP1572962.
JD408116 - Sequence 389140 from Patent EP1572962.
JD205698 - Sequence 186722 from Patent EP1572962.
JD133498 - Sequence 114522 from Patent EP1572962.
JD534954 - Sequence 515978 from Patent EP1572962.
JD349490 - Sequence 330514 from Patent EP1572962.
JD403011 - Sequence 384035 from Patent EP1572962.
JD162517 - Sequence 143541 from Patent EP1572962.
JD566947 - Sequence 547971 from Patent EP1572962.
JD565380 - Sequence 546404 from Patent EP1572962.
JD437572 - Sequence 418596 from Patent EP1572962.
JD046509 - Sequence 27533 from Patent EP1572962.
JD346148 - Sequence 327172 from Patent EP1572962.
JD076972 - Sequence 57996 from Patent EP1572962.
JD396284 - Sequence 377308 from Patent EP1572962.
JD373095 - Sequence 354119 from Patent EP1572962.
JD444420 - Sequence 425444 from Patent EP1572962.
JD550783 - Sequence 531807 from Patent EP1572962.
JD427853 - Sequence 408877 from Patent EP1572962.
JD221179 - Sequence 202203 from Patent EP1572962.
JD439234 - Sequence 420258 from Patent EP1572962.
JD093422 - Sequence 74446 from Patent EP1572962.
JD149037 - Sequence 130061 from Patent EP1572962.
JD515936 - Sequence 496960 from Patent EP1572962.
JD376208 - Sequence 357232 from Patent EP1572962.
JD340435 - Sequence 321459 from Patent EP1572962.
JD128280 - Sequence 109304 from Patent EP1572962.
JD301161 - Sequence 282185 from Patent EP1572962.
JD481142 - Sequence 462166 from Patent EP1572962.
JD291890 - Sequence 272914 from Patent EP1572962.
JD133262 - Sequence 114286 from Patent EP1572962.
MA444999 - JP 2018138019-A/16925: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9UHR5 (Reactome details) participates in the following event(s):

R-HSA-427409 Nucleolar Remodelling Complex (NoRC) binds intergenic region of rDNA
R-HSA-5227490 NoRC:HDAC:DNMT methylates cytosine of the rRNA genes
R-HSA-427413 NoRC negatively regulates rRNA expression
R-HSA-5250941 Negative epigenetic regulation of rRNA expression
R-HSA-212165 Epigenetic regulation of gene expression
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: B3KML7, HCNGP, HTRG, HTRP, NM_013260, NP_037392, Q8N1R5, Q8TDR8, Q96D27, Q9UHR5, S30BP_HUMAN
UCSC ID: uc002jpe.3
RefSeq Accession: NM_013260
Protein: Q9UHR5 (aka S30BP_HUMAN)
CCDS: CCDS11726.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_013260.6
exon count: 11CDS single in 3' UTR: no RNA size: 2519
ORF size: 927CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2054.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.