Description: Homo sapiens selectin P (granule membrane protein 140kDa, antigen CD62) (SELP), mRNA. RefSeq Summary (NM_003005): This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr1:169,558,088-169,599,377 Size: 41,290 Total Exon Count: 17 Strand: - Coding Region Position: hg19 chr1:169,559,386-169,599,312 Size: 39,927 Coding Exon Count: 16
Alzheimer Disease S J Furney et al. Molecular psychiatry 2011, Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease., Molecular psychiatry.
[PubMed 21116278]
Atherosclerosis Kelly A Volcik , et al. Clinical chemistry 2009 55(6):1076-82, SELP and SELPLG genetic variation is associated with cell surface measures of SELP and SELPLG: the Atherosclerosis Risk in Communities Carotid MRI Study., Clinical chemistry 2009 55(6):1076-82.
[PubMed 19395438]
Specific SELP and SELPLG polymorphisms were associated with cell surface measures of SELP and SELPLG in both whites and African Americans in the ARIC Carotid MRI Study.
atherosclerosis, coronary Bugert, P. et al. 2004, Polymorphisms in the P-selectin (CD62P) and P-selectin glycoprotein ligand-1 (PSGL-1) genes and coronary heart disease, Clinical chemistry and laboratory medicine. 2004 ;42(9):997-1004.
[PubMed 15497463]
The molecular characterization of P-selectin and PSGL-1 in a case-control study including CHD patients and healthy controls revealed evidence for association of the genes with development of the disease. However, the functional role of the gene variants should be elucidated by further experimental data.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q5R349
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
