Human Gene PRDM15 (uc002yzq.1)
Description: Homo sapiens PR domain containing 15 (PRDM15), transcript variant 1, mRNA.
Transcript (Including UTRs)
Position: hg19 chr21:43,221,154-43,299,591 Size: 78,438 Total Exon Count: 31 Strand: -
Coding Region
Position: hg19 chr21:43,221,400-43,299,480 Size: 78,081 Coding Exon Count: 31
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: PRD15_HUMAN
DESCRIPTION: RecName: Full=PR domain zinc finger protein 15; AltName: Full=PR domain-containing protein 15; AltName: Full=Zinc finger protein 298;
FUNCTION: May be involved in transcriptional regulation.SUBCELLULAR LOCATION: Nucleus (Potential).SIMILARITY: Contains 16 C2H2-type zinc fingers.SIMILARITY: Contains 1 SET domain.SEQUENCE CAUTION: Sequence=AAL60596.1; Type=Erroneous initiation; Sequence=AAM53515.1; Type=Erroneous translation; Note=Erroneous CDS prediction; Sequence=AAM53516.1; Type=Erroneous translation; Note=Erroneous CDS prediction; Sequence=BAA95527.1; Type=Erroneous gene model prediction;
Primer design for this transcript
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): PRDM15
CDC HuGE Published Literature: PRDM15
Positive Disease Associations: Body Height
, Myocardial Infarction
, Parkinson Disease
, Suntan
, tanning
Related Studies: Body Height , , .
[PubMed 0 ]
Myocardial Infarction , , .
[PubMed 0 ]
Parkinson Disease Nathan Pankratz et al. Annals of neurology 2012, Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2., Annals of neurology.
[PubMed 22451204 ]
We identified a novel PD susceptibility locus, RIT2, replicated several previously identified loci, and identified more than 1 risk allele within SNCA and GBA.
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Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR001214 - SET_dom
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd
Pfam Domains: PF00096 - Zinc finger, C2H2 type
PF12874 - Zinc-finger of C2H2 type
PF13894 - C2H2-type zinc finger
PF13913 - zinc-finger of a C2HC-type
SCOP Domains: 57667 - C2H2 and C2HC zinc fingers
ModBase Predicted Comparative 3D Structure on P57071
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse Rat Zebrafish D. melanogaster C. elegans S. cerevisiae
No ortholog No ortholog No ortholog No ortholog No ortholog No ortholog
Gene Details
Gene Sorter
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
BC067102 - Homo sapiens PR domain containing 15, mRNA (cDNA clone MGC:71480 IMAGE:5925140), complete cds.AB051812 - Homo sapiens mRNA for zinc finger protein ZNF298a, complete cds.AB051813 - Homo sapiens mRNA for zinc finger protein ZNF298b, complete cds.AB051814 - Homo sapiens mRNA for zinc finger protein ZNF298c, complete cds.AB051815 - Homo sapiens mRNA for zinc finger protein ZNF298d, complete cds.AY078498 - Homo sapiens zinc finger 298 mRNA, complete cds.KJ903045 - Synthetic construct Homo sapiens clone ccsbBroadEn_12439 PRDM15 gene, encodes complete protein.BC032305 - Homo sapiens cDNA clone IMAGE:5181414, **** WARNING: chimeric clone ****.AF276513 - Homo sapiens PR-domain zinc finger protein 15 (PRDM15) mRNA, partial cds.AL109788 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 814590.AF426259 - Homo sapiens putative C21orf83B protein form A (C21orf83) mRNA, complete cds.AF426260 - Homo sapiens putative C21orf83B protein form B (C21orf83) mRNA, complete cds.AY063456 - Homo sapiens C21orf83 isoform C (C21orf83) mRNA, complete cds.JD085990 - Sequence 67014 from Patent EP1572962.JD235309 - Sequence 216333 from Patent EP1572962.JD060581 - Sequence 41605 from Patent EP1572962.AB209162 - Homo sapiens mRNA for PR domain containing 15 variant protein.JD475527 - Sequence 456551 from Patent EP1572962.MP509265 - Sequence 76 from Patent EP3506910.
Other Names for This Gene
Alternate Gene Symbols: C21orf83, NM_022115, NP_071398, P57071, PRD15_HUMAN, Q8N0X3, Q8NEX0, Q9NQV3, ZNF298UCSC ID: uc002yzq.1RefSeq Accession: NM_022115
Protein: P57071
(aka PRD15_HUMAN or PRDF_HUMAN)
CCDS: CCDS13676.1
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_022115.3
exon count:
31 CDS single in 3' UTR:
no
RNA size:
4710
ORF size:
4524 CDS single in intron:
no
Alignment % ID:
100.00
txCdsPredict score:
7799.00 frame shift in genome:
no
% Coverage:
100.00
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.