ID:SYC2L_HUMAN DESCRIPTION: RecName: Full=Synaptonemal complex protein 2-like; Short=SCP-2-like; AltName: Full=145 kDa nucleolar protein homolog; Short=hsNO145; SUBCELLULAR LOCATION: Nucleus. Note=Detected in nuclear granules and sizable aggregates. TISSUE SPECIFICITY: Expressed in the ovary (at protein level). SIMILARITY: Belongs to the SYCP2 family. SEQUENCE CAUTION: Sequence=CAI16226.1; Type=Erroneous gene model prediction; Sequence=CAI22075.1; Type=Erroneous gene model prediction;
Cholesterol, LDL Sekar Kathiresan et al. BMC medical genetics 2007, A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study., BMC medical genetics.
[PubMed 17903299]
Using a 100K genome-wide scan, we have generated a set of putative associations for common sequence variants and lipid phenotypes. Validation of selected hypotheses in additional samples did not identify any new loci underlying variability in blood lipids. Lack of replication may be due to inadequate statistical power to detect modest quantitative trait locus effects (i.e., <1% of trait variance explained) or reduced genomic coverage of the 100K array. GWAS in FHS using a denser genome-wide genotyping platform and a better-powered replication strategy may identify novel loci underlying blood lipids.
Menarche Chunyan He et al. Nature genetics 2009, Genome-wide association studies identify loci associated with age at menarche and age at natural menopause., Nature genetics.
[PubMed 19448621]
menarche and menopause (age at onset) He ,et al. 2009, Genome-wide association studies identify loci associated with age at menarche and age at natural menopause, Nature genetics 2009 .
[PubMed 19448621]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q5T4T6
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK294018 - Homo sapiens cDNA FLJ60468 complete cds, weakly similar to Synaptonemal complex protein 2. AK128130 - Homo sapiens cDNA FLJ46251 fis, clone TESTI4021713, weakly similar to Homo sapiens synaptonemal complex protein 2 (SYCP2). AM293674 - Homo sapiens mRNA for 145 kDa nucleolar protein (NO145 gene). BC012225 - Homo sapiens synaptonemal complex protein 2-like, mRNA (cDNA clone IMAGE:3452587), partial cds. JD330440 - Sequence 311464 from Patent EP1572962. JD193561 - Sequence 174585 from Patent EP1572962. JD064767 - Sequence 45791 from Patent EP1572962. JD543063 - Sequence 524087 from Patent EP1572962.