Description: Homo sapiens cyclin T2 (CCNT2), transcript variant b, mRNA. RefSeq Summary (NM_058241): The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. A pseudogene of this gene is found on chromosome 1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]. Transcript (Including UTRs) Position: hg19 chr2:135,676,392-135,716,915 Size: 40,524 Total Exon Count: 9 Strand: + Coding Region Position: hg19 chr2:135,676,425-135,712,218 Size: 35,794 Coding Exon Count: 9
ID:CCNT2_HUMAN DESCRIPTION: RecName: Full=Cyclin-T2; Short=CycT2; FUNCTION: Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II). SUBUNIT: Associates with CDK9 to form P-TEFb. Isoform 1 and isoform 2 interact with HIV-2 and SIV Tat. Does not bind efficiently to the transactivation domain of the HIV-1 Tat. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Ubiquitously expressed. SIMILARITY: Belongs to the cyclin family. Cyclin C subfamily. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/ccnt2/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O60583
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0001223 transcription coactivator binding GO:0003682 chromatin binding GO:0004674 protein serine/threonine kinase activity GO:0005515 protein binding GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity GO:0019901 protein kinase binding GO:0070063 RNA polymerase binding GO:0097322 7SK snRNA binding
Biological Process: GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0006368 transcription elongation from RNA polymerase II promoter GO:0006468 protein phosphorylation GO:0007049 cell cycle GO:0007519 skeletal muscle tissue development GO:0016032 viral process GO:0019085 early viral transcription GO:0019086 late viral transcription GO:0042795 snRNA transcription from RNA polymerase II promoter GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0051147 regulation of muscle cell differentiation GO:0051301 cell division GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain
BX648174 - Homo sapiens mRNA; cDNA DKFZp686O1432 (from clone DKFZp686O1432). AK294889 - Homo sapiens cDNA FLJ58505 complete cds, highly similar to Cyclin-T2. AF048731 - Homo sapiens cyclin T2a mRNA, complete cds. AK292913 - Homo sapiens cDNA FLJ77556 complete cds, highly similar to Homo sapiens cyclin T2 (CCNT2), transcript variant b, mRNA. BC114366 - Homo sapiens cyclin T2, mRNA (cDNA clone MGC:134840 IMAGE:40053797), complete cds. AF048732 - Homo sapiens cyclin T2b mRNA, complete cds. AK075041 - Homo sapiens cDNA FLJ90560 fis, clone OVARC1001086, highly similar to Homo sapiens cyclin T2a mRNA. JD310069 - Sequence 291093 from Patent EP1572962. JD054919 - Sequence 35943 from Patent EP1572962. JD350570 - Sequence 331594 from Patent EP1572962. JD567115 - Sequence 548139 from Patent EP1572962. JD251400 - Sequence 232424 from Patent EP1572962. JD382875 - Sequence 363899 from Patent EP1572962. JD357594 - Sequence 338618 from Patent EP1572962. JD508985 - Sequence 490009 from Patent EP1572962. JD437090 - Sequence 418114 from Patent EP1572962. JD280057 - Sequence 261081 from Patent EP1572962. JD496756 - Sequence 477780 from Patent EP1572962. JD249287 - Sequence 230311 from Patent EP1572962. JD557842 - Sequence 538866 from Patent EP1572962. JD048405 - Sequence 29429 from Patent EP1572962. JD551715 - Sequence 532739 from Patent EP1572962. JD506467 - Sequence 487491 from Patent EP1572962. JD047383 - Sequence 28407 from Patent EP1572962. JD314606 - Sequence 295630 from Patent EP1572962. AK023645 - Homo sapiens cDNA FLJ13583 fis, clone PLACE1009050.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O60583 (Reactome details) participates in the following event(s):
R-HSA-112430 Formation of P-TEFb complex R-HSA-112381 Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex R-HSA-167084 Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex R-HSA-6810234 General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene R-HSA-113429 Elongating transcript encounters a lesion in the template R-HSA-112379 Recruitment of elongation factors to form elongation complex R-HSA-113411 2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing R-HSA-113412 Pol II elongation complex moves on the template as transcript elongates R-HSA-113414 7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest R-HSA-112385 Addition of nucleotides leads to transcript elongation R-HSA-112392 Resumption of elongation after recovery from pausing R-HSA-113413 TFIIS-mediated recovery of elongation from arrest R-HSA-112395 Abortive termination of elongation after arrest R-HSA-112396 Separation of elongating transcript from template R-HSA-167077 Recruitment of elongation factors to form HIV-1 elongation complex R-HSA-167282 2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing R-HSA-167284 7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest R-HSA-167288 TFIIS-mediated recovery of HIV-1 elongation from arrest R-HSA-167292 Resumption of elongation of HIV-1 transcript after recovery from pausing R-HSA-167481 Abortive termination of HIV-1 elongation after arrest R-HSA-6810238 RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) R-HSA-6797616 CCNK:CDK12 binds RNA Pol II at DNA repair genes R-HSA-6810235 RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain R-HSA-6810233 CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter R-HSA-6814885 CBCAP complex binds 7-methylguanosine cap of snRNA R-HSA-2176475 Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 R-HSA-6797606 CDK12 phosphorylates RNA Pol II CTD at DNA repair genes R-HSA-674695 RNA Polymerase II Pre-transcription Events R-HSA-112382 Formation of RNA Pol II elongation complex R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat R-HSA-6807505 RNA polymerase II transcribes snRNA genes R-HSA-73857 RNA Polymerase II Transcription R-HSA-75955 RNA Polymerase II Transcription Elongation R-HSA-167290 Pausing and recovery of HIV elongation R-HSA-167287 HIV elongation arrest and recovery R-HSA-167172 Transcription of the HIV genome R-HSA-74160 Gene expression (Transcription) R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-162599 Late Phase of HIV Life Cycle R-HSA-3700989 Transcriptional Regulation by TP53 R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-162587 HIV Life Cycle R-HSA-212436 Generic Transcription Pathway R-HSA-170834 Signaling by TGF-beta Receptor Complex R-HSA-162906 HIV Infection R-HSA-9006936 Signaling by TGF-beta family members R-HSA-5663205 Infectious disease R-HSA-162582 Signal Transduction R-HSA-1643685 Disease
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