Description: Homo sapiens tyrosine kinase with immunoglobulin-like and EGF-like domains 1 (TIE1), transcript variant 1, mRNA. RefSeq Summary (NM_005424): This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]. Transcript (Including UTRs) Position: hg19 chr1:43,766,566-43,788,781 Size: 22,216 Total Exon Count: 23 Strand: + Coding Region Position: hg19 chr1:43,766,743-43,788,393 Size: 21,651 Coding Exon Count: 23
ID:TIE1_HUMAN DESCRIPTION: RecName: Full=Tyrosine-protein kinase receptor Tie-1; EC=2.7.10.1; Flags: Precursor; FUNCTION: Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis. CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SUBUNIT: Heterodimer with TEK/TIE2. INTERACTION: Q15238:PSG5; NbExp=3; IntAct=EBI-2256865, EBI-4314891; SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Specifically expressed in developing vascular endothelial cells. PTM: Phosphorylated on tyrosine residues in response to ANGPT1, most likely by TEK/TIE2. SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily. SIMILARITY: Contains 3 EGF-like domains. SIMILARITY: Contains 3 fibronectin type-III domains. SIMILARITY: Contains 2 Ig-like C2-type (immunoglobulin-like) domains. SIMILARITY: Contains 1 protein kinase domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00041 - Fibronectin type III domain PF00047 - Immunoglobulin domain PF00069 - Protein kinase domain PF07714 - Protein tyrosine kinase PF12661 - Human growth factor-like EGF
SCOP Domains: 48726 - Immunoglobulin 49265 - Fibronectin type III 56112 - Protein kinase-like (PK-like) 57196 - EGF/Laminin
ModBase Predicted Comparative 3D Structure on P35590
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
