Description: Homo sapiens solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 (SLC25A24), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA. RefSeq Summary (NM_013386): This gene encodes a carrier protein that transports ATP-Mg exchanging it for phosphate. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]. Transcript (Including UTRs) Position: hg19 chr1:108,677,344-108,742,980 Size: 65,637 Total Exon Count: 10 Strand: - Coding Region Position: hg19 chr1:108,679,275-108,742,760 Size: 63,486 Coding Exon Count: 10
ID:SCMC1_HUMAN DESCRIPTION: RecName: Full=Calcium-binding mitochondrial carrier protein SCaMC-1; AltName: Full=Mitochondrial ATP-Mg/Pi carrier protein 1; AltName: Full=Mitochondrial Ca(2+)-dependent solute carrier protein 1; AltName: Full=Small calcium-binding mitochondrial carrier protein 1; AltName: Full=Solute carrier family 25 member 24; FUNCTION: Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.97 mM for AMP; KM=0.3 mM for ADP; KM=0.33 mM for ATP; KM=0.2 mM for ATP-Mg; KM=1.64 mM for Pi; Vmax=337 umol/min/g enzyme with AMP as substrate; Vmax=345 umol/min/g enzyme with ADP as substrate; Vmax=320 umol/min/g enzyme with ATP as substrate; Vmax=365 umol/min/g enzyme with ATP-Mg as substrate; Vmax=380 umol/min/g enzyme with Pi as substrate; SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Present in various cell lines (at protein level). Expressed in all tissues tested. Highly expressed in testis, expressed at intermediate level in small intestine and pancreas, and weakly expressed in kidney, spleen, liver, skeletal muscle and heart. SIMILARITY: Belongs to the mitochondrial carrier family. SIMILARITY: Contains 4 EF-hand domains. SIMILARITY: Contains 3 Solcar repeats. SEQUENCE CAUTION: Sequence=AAF28888.1; Type=Frameshift; Positions=418, 464; Sequence=CAI13622.1; Type=Erroneous gene model prediction; Sequence=CAI14512.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6NUK1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005347 ATP transmembrane transporter activity GO:0005509 calcium ion binding GO:0015217 ADP transmembrane transporter activity GO:0046872 metal ion binding
US Server
