Description: Homo sapiens ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) (RAC1), transcript variant Rac1b, mRNA. RefSeq Summary (NM_018890): The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]. Transcript (Including UTRs) Position: hg19 chr7:6,414,126-6,443,598 Size: 29,473 Total Exon Count: 7 Strand: + Coding Region Position: hg19 chr7:6,414,367-6,442,077 Size: 27,711 Coding Exon Count: 7
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on A4D2P0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BioCarta from NCI Cancer Genome Anatomy Project h_actinYPathway - Y branching of actin filaments h_arfPathway - Tumor Suppressor Arf Inhibits Ribosomal Biogenesis h_pyk2Pathway - Links between Pyk2 and Map Kinases h_bcrPathway - BCR Signaling Pathway h_crebPathway - Transcription factor CREB and its extracellular signals h_fMLPpathway - fMLP induced chemokine gene expression in HMC-1 cells h_rac1Pathway - Rac 1 cell motility signaling pathway h_rasPathway - Ras Signaling Pathway h_tcrPathway - T Cell Receptor Signaling Pathway h_ptdinsPathway - Phosphoinositides and their downstream targets. h_cdc42racPathway - Role of PI3K subunit p85 in regulation of Actin Organization and Cell Migration h_salmonellaPathway - How does salmonella hijack a cell h_At1rPathway - Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling h_malPathway - Role of MAL in Rho-Mediated Activation of SRF h_nkcellsPathway - Ras-Independent pathway in NK cell-mediated cytotoxicity h_ucalpainPathway - uCalpain and friends in Cell spread h_agrPathway - Agrin in Postsynaptic Differentiation h_edg1Pathway - Phospholipids as signalling intermediaries h_RacCycDPathway - Influence of Ras and Rho proteins on G1 to S Transition h_mapkPathway - MAPKinase Signaling Pathway h_p38mapkPathway - p38 MAPK Signaling Pathway
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