Human Gene C1orf122 (uc001ccd.2)
  Description: Homo sapiens chromosome 1 open reading frame 122 (C1orf122), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr1:38,273,473-38,275,126 Size: 1,654 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr1:38,274,077-38,274,745 Size: 669 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:38,273,473-38,275,126)mRNA (may differ from genome)Protein (110 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMGIneXtProt
PubMedTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CA122_HUMAN
DESCRIPTION: RecName: Full=Uncharacterized protein C1orf122; AltName: Full=Protein ALAESM;
SEQUENCE CAUTION: Sequence=AAH57819.1; Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=BAC86950.1; Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=CAH70085.1; Type=Erroneous translation; Note=Wrong choice of CDS;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): C1orf122
CDC HuGE Published Literature: C1orf122

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 156.59 RPKM in Brain - Spinal cord (cervical c-1)
Total median expression: 3335.74 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -332.30604-0.550 Picture PostScript Text
3' UTR -146.89381-0.386 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF15855 - Domain of unknown function (DUF4726)

ModBase Predicted Comparative 3D Structure on Q6ZSJ8
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Descriptions from all associated GenBank mRNAs
  LF385425 - JP 2014500723-A/192928: Polycomb-Associated Non-Coding RNAs.
LF206608 - JP 2014500723-A/14111: Polycomb-Associated Non-Coding RNAs.
BC016402 - Homo sapiens, clone IMAGE:4177569, mRNA.
MA621002 - JP 2018138019-A/192928: Polycomb-Associated Non-Coding RNAs.
MA442185 - JP 2018138019-A/14111: Polycomb-Associated Non-Coding RNAs.
JD275098 - Sequence 256122 from Patent EP1572962.
AY517499 - Homo sapiens hypothetical protein ALAESM mRNA, complete cds.
JD111516 - Sequence 92540 from Patent EP1572962.
JD163875 - Sequence 144899 from Patent EP1572962.
LF206607 - JP 2014500723-A/14110: Polycomb-Associated Non-Coding RNAs.
JD325357 - Sequence 306381 from Patent EP1572962.
LF356531 - JP 2014500723-A/164034: Polycomb-Associated Non-Coding RNAs.
BC107856 - Homo sapiens chromosome 1 open reading frame 122, mRNA (cDNA clone IMAGE:5239581).
LF213509 - JP 2014500723-A/21012: Polycomb-Associated Non-Coding RNAs.
BC057819 - Homo sapiens chromosome 1 open reading frame 122, mRNA (cDNA clone MGC:71776 IMAGE:4792982), complete cds.
AK127381 - Homo sapiens cDNA FLJ45459 fis, clone BRSTN2010416.
BC127187 - Homo sapiens chromosome 1 open reading frame 122, mRNA (cDNA clone IMAGE:40035129), partial cds.
BC102041 - Homo sapiens cDNA clone IMAGE:40035904, partial cds.
BC127188 - Homo sapiens chromosome 1 open reading frame 122, mRNA (cDNA clone IMAGE:40035130), partial cds.
BC141938 - Homo sapiens cDNA clone IMAGE:40035905, partial cds.
LF356530 - JP 2014500723-A/164033: Polycomb-Associated Non-Coding RNAs.
JD217629 - Sequence 198653 from Patent EP1572962.
KJ903738 - Synthetic construct Homo sapiens clone ccsbBroadEn_13132 C1orf122 gene, encodes complete protein.
LF356529 - JP 2014500723-A/164032: Polycomb-Associated Non-Coding RNAs.
JD374735 - Sequence 355759 from Patent EP1572962.
JD344995 - Sequence 326019 from Patent EP1572962.
JD426880 - Sequence 407904 from Patent EP1572962.
JD224818 - Sequence 205842 from Patent EP1572962.
JD206315 - Sequence 187339 from Patent EP1572962.
JD426786 - Sequence 407810 from Patent EP1572962.
JD382889 - Sequence 363913 from Patent EP1572962.
JD114582 - Sequence 95606 from Patent EP1572962.
MA442184 - JP 2018138019-A/14110: Polycomb-Associated Non-Coding RNAs.
MA592108 - JP 2018138019-A/164034: Polycomb-Associated Non-Coding RNAs.
MA449086 - JP 2018138019-A/21012: Polycomb-Associated Non-Coding RNAs.
MA592107 - JP 2018138019-A/164033: Polycomb-Associated Non-Coding RNAs.
MA592106 - JP 2018138019-A/164032: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: A2RQF4, CA122_HUMAN, NM_198446, NP_940848, Q56A71, Q6ZSJ8, uc001ccb.1
UCSC ID: uc001ccd.2
RefSeq Accession: NM_198446
Protein: Q6ZSJ8 (aka CA122_HUMAN)
CCDS: CCDS427.2

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_198446.2
exon count: 3CDS single in 3' UTR: no RNA size: 1359
ORF size: 333CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1115.00frame shift in genome: no % Coverage: 96.98
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.