Description: Homo sapiens HGF activator (HGFAC), mRNA. RefSeq Summary (NM_001528): This gene encodes a member of the peptidase S1 protein family. The encoded protein is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing. It acts as serine protease that converts hepatocyte growth factor to the active form. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]. Transcript (Including UTRs) Position: hg19 chr4:3,443,726-3,451,213 Size: 7,488 Total Exon Count: 14 Strand: + Coding Region Position: hg19 chr4:3,443,729-3,451,146 Size: 7,418 Coding Exon Count: 14
ID:HGFA_HUMAN DESCRIPTION: RecName: Full=Hepatocyte growth factor activator; Short=HGF activator; Short=HGFA; EC=3.4.21.-; Contains: RecName: Full=Hepatocyte growth factor activator short chain; Contains: RecName: Full=Hepatocyte growth factor activator long chain; Flags: Precursor; FUNCTION: Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form. SUBUNIT: Heterodimer of a short chain and a long chain linked by a disulfide bond. SUBCELLULAR LOCATION: Secreted. Note=Secreted as an inactive single-chain precursor and is then activated to a heterodimeric form. TISSUE SPECIFICITY: Liver. SIMILARITY: Belongs to the peptidase S1 family. SIMILARITY: Contains 2 EGF-like domains. SIMILARITY: Contains 1 fibronectin type-I domain. SIMILARITY: Contains 1 fibronectin type-II domain. SIMILARITY: Contains 1 kringle domain. SIMILARITY: Contains 1 peptidase S1 domain. CAUTION: It is uncertain whether Met-1 is the initiator.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q04756
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC112190 - Homo sapiens HGF activator, mRNA (cDNA clone MGC:138395 IMAGE:8327658), complete cds. BC112192 - Homo sapiens HGF activator, mRNA (cDNA clone MGC:138397 IMAGE:8327660), complete cds. AK314099 - Homo sapiens cDNA, FLJ94782. D14012 - Homo sapiens mRNA for HGF activator precursor, complete cds. KJ896969 - Synthetic construct Homo sapiens clone ccsbBroadEn_06363 HGFAC gene, encodes complete protein. E07591 - DNA encoding a protease that catalyzes converting reaction of HGF from single-stranded inactive form to double-stranded active form. E07615 - DNA encoding a protease that catalyzes converting reaction of HGF from single-stranded inactive form to double-stranded active form. E07590 - DNA encoding a protease that catalyzes converting reaction of HGF from single-stranded inactive form to double-stranded active form. E07614 - DNA encoding a protease that catalyzes converting reaction of HGF from single-stranded inactive form to double-stranded active form.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q04756 (Reactome details) participates in the following event(s):
US Server
