Description: Homo sapiens solute carrier family 38, member 4 (SLC38A4), transcript variant 2, mRNA. RefSeq Summary (NM_001143824): SLC38A4 is found predominantly in liver and transports both cationic and neutral amino acids. The transport of cationic amino acids by SLC38A4 is Na(+) and pH independent, while the transport of neutral amino acids is Na(+) and pH dependent (Hatanaka et al., 2001 [PubMed 11342143]).[supplied by OMIM, Mar 2008]. Transcript (Including UTRs) Position: hg19 chr12:47,158,544-47,219,780 Size: 61,237 Total Exon Count: 16 Strand: - Coding Region Position: hg19 chr12:47,160,484-47,186,854 Size: 26,371 Coding Exon Count: 15
ID:S38A4_HUMAN DESCRIPTION: RecName: Full=Sodium-coupled neutral amino acid transporter 4; AltName: Full=Amino acid transporter A3; AltName: Full=Na(+)-coupled neutral amino acid transporter 4; AltName: Full=Solute carrier family 38 member 4; AltName: Full=System A amino acid transporter 3; AltName: Full=System N amino acid transporter 3; FUNCTION: Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium ions. Has a broad specificity, with a preference for Ala, followed by His, Cys, Asn, Ser, Gly, Val, Thr, Gln and Met. May mediate sodium- independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is pH-dependent, with low transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5. BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 7.5-8.5; SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Detected in embryonic and adult liver, and at lower levels in adult muscle, kidney and pancreas. Detected in placenta syncytiotrophoblasts throughout gestation. Detected in fetal blood vessels. SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF01490 - Transmembrane amino acid transporter protein
ModBase Predicted Comparative 3D Structure on Q969I6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AB055003 - Homo sapiens hATA3 mRNA for system A amino acid transporter 3, complete cds. AF305814 - Homo sapiens amino acid transporter system A3 (ATA3) mRNA, complete cds. AK001053 - Homo sapiens cDNA FLJ10191 fis, clone HEMBA1004756, weakly similar to Human transporter protein mRNA. AK291168 - Homo sapiens cDNA FLJ76186 complete cds, highly similar to Homo sapiens solute carrier family 38, member 4 (SLC38A4), mRNA. AF193836 - Homo sapiens amino acid transporter hNAT3 mRNA, complete cds. BC069819 - Homo sapiens solute carrier family 38, member 4, mRNA (cDNA clone MGC:97157 IMAGE:7262399), complete cds. BC104913 - Homo sapiens solute carrier family 38, member 4, mRNA (cDNA clone MGC:132573 IMAGE:8143916), complete cds. BC101827 - Homo sapiens solute carrier family 38, member 4, mRNA (cDNA clone MGC:126876 IMAGE:8069333), complete cds. KJ899073 - Synthetic construct Homo sapiens clone ccsbBroadEn_08467 SLC38A4 gene, encodes complete protein. JD236940 - Sequence 217964 from Patent EP1572962. JD084943 - Sequence 65967 from Patent EP1572962. JD502239 - Sequence 483263 from Patent EP1572962. JD051296 - Sequence 32320 from Patent EP1572962. JD081697 - Sequence 62721 from Patent EP1572962. JD427230 - Sequence 408254 from Patent EP1572962. JD062268 - Sequence 43292 from Patent EP1572962. JD102598 - Sequence 83622 from Patent EP1572962. JD349881 - Sequence 330905 from Patent EP1572962. JD304335 - Sequence 285359 from Patent EP1572962. JD042408 - Sequence 23432 from Patent EP1572962. JD408201 - Sequence 389225 from Patent EP1572962. JD523488 - Sequence 504512 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q969I6 (Reactome details) participates in the following event(s):
R-HSA-352136 SLC38A4 (ATA3)-mediated uptake of arginine and lysine R-HSA-352230 Amino acid transport across the plasma membrane R-HSA-425374 Amino acid and oligopeptide SLC transporters R-HSA-425393 Metabolism of nitrogenous molecules R-HSA-425407 SLC-mediated transmembrane transport R-HSA-382551 Transport of small molecules
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
