Human Gene UGT2B10 (uc011cao.1) Description and Page Index
  Description: Homo sapiens UDP glucuronosyltransferase 2 family, polypeptide B10 (UGT2B10), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr4:69,870,295-69,886,113 Size: 15,819 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg19 chr4:69,870,574-69,885,968 Size: 15,395 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:69,870,295-69,886,113)mRNA (may differ from genome)Protein (528 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblExonPrimerGeneCardsGeneNetwork
HGNCHPRDLynxMGIneXtProtPubMed
ReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: UDB10_HUMAN
DESCRIPTION: RecName: Full=UDP-glucuronosyltransferase 2B10; Short=UDPGT 2B10; EC=2.4.1.17; Flags: Precursor;
FUNCTION: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
CATALYTIC ACTIVITY: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
SUBCELLULAR LOCATION: Microsome membrane; Single-pass membrane protein (Potential). Endoplasmic reticulum membrane; Single-pass membrane protein (Potential).
SIMILARITY: Belongs to the UDP-glycosyltransferase family.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): UGT2B10
CDC HuGE Published Literature: UGT2B10

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.49 RPKM in Liver
Total median expression: 1.53 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -34.50126-0.274 Picture PostScript Text
3' UTR -48.00279-0.172 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002213 - UDP_glucos_trans

Pfam Domains:
PF00201 - UDP-glucoronosyl and UDP-glucosyl transferase
PF04101 - Glycosyltransferase family 28 C-terminal domain

SCOP Domains:
53756 - UDP-Glycosyltransferase/glycogen phosphorylase

ModBase Predicted Comparative 3D Structure on P36537
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0015020 glucuronosyltransferase activity
GO:0016740 transferase activity
GO:0016757 transferase activity, transferring glycosyl groups
GO:0016758 transferase activity, transferring hexosyl groups

Biological Process:
GO:0006629 lipid metabolic process
GO:0008152 metabolic process

Cellular Component:
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031090 organelle membrane
GO:0043231 intracellular membrane-bounded organelle


-  Descriptions from all associated GenBank mRNAs
  AK292738 - Homo sapiens cDNA FLJ76966 complete cds, highly similar to Homo sapiens UDP glucuronosyltransferase 2 family, polypeptide B10 (UGT2B10), mRNA.
AK298432 - Homo sapiens cDNA FLJ54605 complete cds, highly similar to UDP-glucuronosyltransferase 2B10 precursor (EC 2.4.1.17).
BC113649 - Homo sapiens UDP glucuronosyltransferase 2 family, polypeptide B10, mRNA (cDNA clone MGC:142209 IMAGE:8322701), complete cds.
AK222872 - Homo sapiens mRNA for UDP glycosyltransferase 2 family, polypeptide B10 variant, clone: HEP14512.
AK222839 - Homo sapiens mRNA for UDP glycosyltransferase 2 family, polypeptide B10 variant, clone: HEP11643.
KJ892358 - Synthetic construct Homo sapiens clone ccsbBroadEn_01752 UGT2B10 gene, encodes complete protein.
JD491703 - Sequence 472727 from Patent EP1572962.
JD281735 - Sequence 262759 from Patent EP1572962.
JD457793 - Sequence 438817 from Patent EP1572962.
JD181464 - Sequence 162488 from Patent EP1572962.
JD323499 - Sequence 304523 from Patent EP1572962.
JD495038 - Sequence 476062 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00040 - Pentose and glucuronate interconversions
hsa00053 - Ascorbate and aldarate metabolism
hsa00140 - Steroid hormone biosynthesis
hsa00500 - Starch and sucrose metabolism
hsa00830 - Retinol metabolism
hsa00860 - Porphyrin and chlorophyll metabolism
hsa00980 - Metabolism of xenobiotics by cytochrome P450
hsa00982 - Drug metabolism - cytochrome P450
hsa00983 - Drug metabolism - other enzymes
hsa01100 - Metabolic pathways

Reactome (by CSHL, EBI, and GO)

Protein P36537 (Reactome details) participates in the following event(s):

R-HSA-174931 UGTs transfer GlcA from UDP-GlcA to O-centre substrates
R-HSA-156588 Glucuronidation
R-HSA-156580 Phase II - Conjugation of compounds
R-HSA-211859 Biological oxidations
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: A8K9M3, NM_001075, P36537, Q14CR8, UDB10_HUMAN
UCSC ID: uc011cao.1
RefSeq Accession: NM_001075
Protein: P36537 (aka UDB10_HUMAN)

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001075.4
exon count: 7CDS single in 3' UTR: no RNA size: 2756
ORF size: 1455CDS single in intron: no Alignment % ID: 96.71
txCdsPredict score: 1631.00frame shift in genome: yes % Coverage: 67.31
has start codon: yes stop codon in genome: no # of Alignments: 4
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 1
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.