Human Gene ZNF658B (uc004abx.3) Description and Page Index
  Description: Homo sapiens zinc finger protein 658B, pseudogene (ZNF658B), non-coding RNA.
Transcript (Including UTRs)
   Position: hg19 chr9:41,588,837-41,592,207 Size: 3,371 Total Exon Count: 1 Strand: -
Coding Region
   Position: hg19 chr9:41,589,516-41,591,975 Size: 2,460 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:41,588,837-41,592,207)mRNA (may differ from genome)Protein (819 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPExonPrimerGeneCardsH-INVHGNCLynx
MGIneXtProtPubMedReactomeStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: Z658B_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 658B;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 21 C2H2-type zinc fingers.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -54.30232-0.234 Picture PostScript Text
3' UTR -151.64679-0.223 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF12874 - Zinc-finger of C2H2 type
PF13912 - C2H2-type zinc finger

SCOP Domains:
48695 - Multiheme cytochromes
57667 - C2H2 and C2HC zinc fingers
57889 - Cysteine-rich domain

ModBase Predicted Comparative 3D Structure on Q4V348
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
    Gene Details 
    Gene Sorter 
    WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  JD438548 - Sequence 419572 from Patent EP1572962.
JD539914 - Sequence 520938 from Patent EP1572962.
AK095694 - Homo sapiens cDNA FLJ38375 fis, clone FEBRA2002611, weakly similar to ZINC FINGER PROTEIN 91.
BC137089 - Homo sapiens zinc finger protein 658, mRNA (cDNA clone MGC:168709 IMAGE:9021086), complete cds.
JD552145 - Sequence 533169 from Patent EP1572962.
JD327404 - Sequence 308428 from Patent EP1572962.
JD435839 - Sequence 416863 from Patent EP1572962.
AB527429 - Synthetic construct DNA, clone: pF1KB9127, Homo sapiens ZNF658B gene for zinc finger protein 658B, without stop codon, in Flexi system.
JD044743 - Sequence 25767 from Patent EP1572962.
JD306489 - Sequence 287513 from Patent EP1572962.
JD282956 - Sequence 263980 from Patent EP1572962.
JD521174 - Sequence 502198 from Patent EP1572962.
JD098045 - Sequence 79069 from Patent EP1572962.
JD172212 - Sequence 153236 from Patent EP1572962.
JD248189 - Sequence 229213 from Patent EP1572962.
JD084449 - Sequence 65473 from Patent EP1572962.
JD050401 - Sequence 31425 from Patent EP1572962.
JD434042 - Sequence 415066 from Patent EP1572962.
JD289465 - Sequence 270489 from Patent EP1572962.
JD414174 - Sequence 395198 from Patent EP1572962.
JD327672 - Sequence 308696 from Patent EP1572962.
JD188341 - Sequence 169365 from Patent EP1572962.
JD109454 - Sequence 90478 from Patent EP1572962.
JD431317 - Sequence 412341 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q4V348 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: NR_027861, Q4V348, Q8N946, Z658B_HUMAN
UCSC ID: uc004abx.3
RefSeq Accession: NR_027861
Protein: Q4V348 (aka Z658B_HUMAN)

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NR_027861.1
exon count: 1CDS single in 3' UTR: no RNA size: 3384
ORF size: 2460CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4572.50frame shift in genome: no % Coverage: 99.62
has start codon: yes stop codon in genome: no # of Alignments: 2
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.