Human Gene ZFP14 (uc010eex.2)
  Description: Homo sapiens ZFP14 zinc finger protein (ZFP14), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr19:36,825,355-36,870,105 Size: 44,751 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr19:36,831,126-36,858,794 Size: 27,669 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:36,825,355-36,870,105)mRNA (may differ from genome)Protein (533 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtPubMedReactomeTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZFP14_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 14 homolog; Short=Zfp-14; AltName: Full=Zinc finger protein 531;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 13 C2H2-type zinc fingers.
SIMILARITY: Contains 1 KRAB domain.
SEQUENCE CAUTION: Sequence=BAB13385.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.03 RPKM in Pituitary
Total median expression: 78.99 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -33.00120-0.275 Picture PostScript Text
3' UTR -1790.295771-0.310 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF01352 - KRAB box
PF12874 - Zinc-finger of C2H2 type
PF13912 - C2H2-type zinc finger

SCOP Domains:
48695 - Multiheme cytochromes
109640 - KRAB domain (Kruppel-associated box, Pfam 01352)
57667 - C2H2 and C2HC zinc fingers

ModBase Predicted Comparative 3D Structure on Q9HCL3
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  BC152446 - Homo sapiens zinc finger protein 14 homolog (mouse), mRNA (cDNA clone MGC:176696 IMAGE:8862575), complete cds.
AB046779 - Homo sapiens KIAA1559 mRNA for KIAA1559 protein.
BC144691 - Homo sapiens cDNA clone IMAGE:9053225.
AK293103 - Homo sapiens cDNA FLJ75848 complete cds, highly similar to Homo sapiens mouse zinc finger protein 14-like, mRNA.
AB384235 - Synthetic construct DNA, clone: pF1KSDA1559, Homo sapiens ZFP14 gene for zinc finger protein 14 homolog, complete cds, without stop codon, in Flexi system.
KJ899363 - Synthetic construct Homo sapiens clone ccsbBroadEn_08757 ZFP14-like gene, encodes complete protein.
JD246857 - Sequence 227881 from Patent EP1572962.
JD413346 - Sequence 394370 from Patent EP1572962.
JD324245 - Sequence 305269 from Patent EP1572962.
JD198056 - Sequence 179080 from Patent EP1572962.
JD173985 - Sequence 155009 from Patent EP1572962.
JD212677 - Sequence 193701 from Patent EP1572962.
JD537264 - Sequence 518288 from Patent EP1572962.
JD221376 - Sequence 202400 from Patent EP1572962.
JD517791 - Sequence 498815 from Patent EP1572962.
JD366600 - Sequence 347624 from Patent EP1572962.
JD185412 - Sequence 166436 from Patent EP1572962.
JD155918 - Sequence 136942 from Patent EP1572962.
JD181640 - Sequence 162664 from Patent EP1572962.
JD518395 - Sequence 499419 from Patent EP1572962.
JD047427 - Sequence 28451 from Patent EP1572962.
JD171522 - Sequence 152546 from Patent EP1572962.
JD530810 - Sequence 511834 from Patent EP1572962.
JD047426 - Sequence 28450 from Patent EP1572962.
JD247800 - Sequence 228824 from Patent EP1572962.
JD147185 - Sequence 128209 from Patent EP1572962.
JD524216 - Sequence 505240 from Patent EP1572962.
JD376856 - Sequence 357880 from Patent EP1572962.
JD386225 - Sequence 367249 from Patent EP1572962.
JD264128 - Sequence 245152 from Patent EP1572962.
JD070826 - Sequence 51850 from Patent EP1572962.
JD105268 - Sequence 86292 from Patent EP1572962.
JD383832 - Sequence 364856 from Patent EP1572962.
JD329065 - Sequence 310089 from Patent EP1572962.
JD420079 - Sequence 401103 from Patent EP1572962.
JD482531 - Sequence 463555 from Patent EP1572962.
JD422004 - Sequence 403028 from Patent EP1572962.
JD119624 - Sequence 100648 from Patent EP1572962.
JD561314 - Sequence 542338 from Patent EP1572962.
JD179591 - Sequence 160615 from Patent EP1572962.
JD481306 - Sequence 462330 from Patent EP1572962.
JD046196 - Sequence 27220 from Patent EP1572962.
JD332636 - Sequence 313660 from Patent EP1572962.
JD295784 - Sequence 276808 from Patent EP1572962.
JD080882 - Sequence 61906 from Patent EP1572962.
JD245035 - Sequence 226059 from Patent EP1572962.
JD175493 - Sequence 156517 from Patent EP1572962.
JD245077 - Sequence 226101 from Patent EP1572962.
JD306174 - Sequence 287198 from Patent EP1572962.
JD503224 - Sequence 484248 from Patent EP1572962.
JD244101 - Sequence 225125 from Patent EP1572962.
JD260381 - Sequence 241405 from Patent EP1572962.
JD341183 - Sequence 322207 from Patent EP1572962.
JD489476 - Sequence 470500 from Patent EP1572962.
JD111593 - Sequence 92617 from Patent EP1572962.
JD236296 - Sequence 217320 from Patent EP1572962.
JD060506 - Sequence 41530 from Patent EP1572962.
JD120872 - Sequence 101896 from Patent EP1572962.
JD320593 - Sequence 301617 from Patent EP1572962.
JD041121 - Sequence 22145 from Patent EP1572962.
JD169108 - Sequence 150132 from Patent EP1572962.
JD529074 - Sequence 510098 from Patent EP1572962.
JD430101 - Sequence 411125 from Patent EP1572962.
JD380570 - Sequence 361594 from Patent EP1572962.
JD326808 - Sequence 307832 from Patent EP1572962.
JD120871 - Sequence 101895 from Patent EP1572962.
JD084345 - Sequence 65369 from Patent EP1572962.
JD169107 - Sequence 150131 from Patent EP1572962.
JD178632 - Sequence 159656 from Patent EP1572962.
JD136268 - Sequence 117292 from Patent EP1572962.
JD099954 - Sequence 80978 from Patent EP1572962.
JD136267 - Sequence 117291 from Patent EP1572962.
JD089444 - Sequence 70468 from Patent EP1572962.
JD427337 - Sequence 408361 from Patent EP1572962.
JD558231 - Sequence 539255 from Patent EP1572962.
JD564284 - Sequence 545308 from Patent EP1572962.
JD053569 - Sequence 34593 from Patent EP1572962.
JD533222 - Sequence 514246 from Patent EP1572962.
JD431235 - Sequence 412259 from Patent EP1572962.
JD101843 - Sequence 82867 from Patent EP1572962.
JD451136 - Sequence 432160 from Patent EP1572962.
JD451135 - Sequence 432159 from Patent EP1572962.
JD486752 - Sequence 467776 from Patent EP1572962.
JD148674 - Sequence 129698 from Patent EP1572962.
JD291030 - Sequence 272054 from Patent EP1572962.
JD566435 - Sequence 547459 from Patent EP1572962.
JD255849 - Sequence 236873 from Patent EP1572962.
JD060918 - Sequence 41942 from Patent EP1572962.
JD348089 - Sequence 329113 from Patent EP1572962.
JD119356 - Sequence 100380 from Patent EP1572962.
JD295933 - Sequence 276957 from Patent EP1572962.
JD566127 - Sequence 547151 from Patent EP1572962.
JD492372 - Sequence 473396 from Patent EP1572962.
JD266013 - Sequence 247037 from Patent EP1572962.
JD235430 - Sequence 216454 from Patent EP1572962.
JD252704 - Sequence 233728 from Patent EP1572962.
JD297603 - Sequence 278627 from Patent EP1572962.
JD331292 - Sequence 312316 from Patent EP1572962.
JD182192 - Sequence 163216 from Patent EP1572962.
JD075206 - Sequence 56230 from Patent EP1572962.
JD209041 - Sequence 190065 from Patent EP1572962.
JD400993 - Sequence 382017 from Patent EP1572962.
JD230605 - Sequence 211629 from Patent EP1572962.
JD172646 - Sequence 153670 from Patent EP1572962.
JD527610 - Sequence 508634 from Patent EP1572962.
JD551918 - Sequence 532942 from Patent EP1572962.
JD247925 - Sequence 228949 from Patent EP1572962.
JD032199 - Sequence 13223 from Patent EP1572962.
JD314887 - Sequence 295911 from Patent EP1572962.
JD314886 - Sequence 295910 from Patent EP1572962.
JD264084 - Sequence 245108 from Patent EP1572962.
JD385671 - Sequence 366695 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9HCL3 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: A7MD23, KIAA1559, NM_020917, NP_065968, Q9HCL3, ZFP14_HUMAN, ZNF531
UCSC ID: uc010eex.2
RefSeq Accession: NM_020917
Protein: Q9HCL3 (aka ZFP14_HUMAN)
CCDS: CCDS33002.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_020917.2
exon count: 5CDS single in 3' UTR: no RNA size: 7502
ORF size: 1602CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3404.00frame shift in genome: no % Coverage: 99.88
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.