Human Gene RP13-511M20.1 (uc002srs.4)
  Description: Homo sapiens required for meiotic nuclear division 5 homolog A (S. cerevisiae) (RP13-511M20.1), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr2:86,947,414-88,038,768 Size: 1,091,355 Total Exon Count: 11 Strand: +
Coding Region
   Position: hg19 chr2:88,019,380-88,038,545 Size: 19,166 Coding Exon Count: 8 

Page IndexSequence and LinksPrimersGene AllelesRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:86,947,414-88,038,768)mRNA (may differ from genome)Protein (368 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGeneCardsGeneNetworkH-INV
LynxMGIPubMedUniProtKB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.41 RPKM in Cells - Cultured fibroblasts
Total median expression: 40.68 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -395.60895-0.442 Picture PostScript Text
3' UTR -60.90223-0.273 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR024990 - Apc1

ModBase Predicted Comparative 3D Structure on B3KM59
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0005680 anaphase-promoting complex


-  Descriptions from all associated GenBank mRNAs
  BC069048 - Homo sapiens anaphase promoting complex subunit 1 pseudogene, mRNA (cDNA clone IMAGE:4111322), complete cds.
AK023972 - Homo sapiens cDNA FLJ13910 fis, clone Y79AA1000131.
AK022815 - Homo sapiens cDNA FLJ12753 fis, clone NT2RP2001226.
BC047668 - Homo sapiens required for meiotic nuclear division 5 homolog A (S. cerevisiae), mRNA (cDNA clone MGC:51764 IMAGE:6066798), complete cds.
JD201799 - Sequence 182823 from Patent EP1572962.
BC012165 - Homo sapiens required for meiotic nuclear division 5 homolog A (S. cerevisiae), mRNA (cDNA clone MGC:20406 IMAGE:4636136), complete cds.
JD192093 - Sequence 173117 from Patent EP1572962.
CU680248 - Synthetic construct Homo sapiens gateway clone IMAGE:100017636 5' read RMND5A mRNA.
CU690448 - Synthetic construct Homo sapiens gateway clone IMAGE:100021420 5' read RMND5A mRNA.
HQ448707 - Synthetic construct Homo sapiens clone IMAGE:100072151; CCSB007218_01 required for meiotic nuclear division 5 homolog A (S. cerevisiae) (RMND5A) gene, encodes complete protein.
KJ894576 - Synthetic construct Homo sapiens clone ccsbBroadEn_03970 RMND5A gene, encodes complete protein.
KJ899476 - Synthetic construct Homo sapiens clone ccsbBroadEn_08870 RMND5A gene, encodes complete protein.
AB528949 - Synthetic construct DNA, clone: pF1KB6542, Homo sapiens RMND5A gene for required for meiotic nuclear division 5 homolog A, without stop codon, in Flexi system.
EU831557 - Synthetic construct Homo sapiens clone HAIB:100066586; DKFZo004F1218 required for meiotic nuclear division 5 homolog A (S. cerevisiae) protein (RMND5A) gene, encodes complete protein.
EU831470 - Synthetic construct Homo sapiens clone HAIB:100066499; DKFZo008F1217 required for meiotic nuclear division 5 homolog A (S. cerevisiae) protein (RMND5A) gene, encodes complete protein.
JD173558 - Sequence 154582 from Patent EP1572962.
AK001223 - Homo sapiens cDNA FLJ10361 fis, clone NT2RM2001256, highly similar to Anaphase-promoting complex subunit 1.
DQ786261 - Homo sapiens clone HLS_IMAGE_292567 mRNA sequence.
JD289687 - Sequence 270711 from Patent EP1572962.
JD476057 - Sequence 457081 from Patent EP1572962.
JD088443 - Sequence 69467 from Patent EP1572962.
JD425188 - Sequence 406212 from Patent EP1572962.
JD531789 - Sequence 512813 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B3KM59, B3KM59_HUMAN, BC069048, RMND5A
UCSC ID: uc002srs.4
RefSeq Accession: NM_022780
Protein: B3KM59

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: BC069048.1
exon count: 11CDS single in 3' UTR: no RNA size: 2007
ORF size: 1107CDS single in intron: no Alignment % ID: 99.59
txCdsPredict score: 1973.50frame shift in genome: no % Coverage: 97.51
has start codon: yes stop codon in genome: no # of Alignments: 2
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.