Human Gene ADARB2 (uc009xhq.3) Description and Page Index
  Description: Homo sapiens adenosine deaminase, RNA-specific, B2 (non-functional) (ADARB2), mRNA.
RefSeq Summary (NM_018702): This gene encodes a member of the double-stranded RNA adenosine deaminase family of RNA-editing enzymes and may play a regulatory role in RNA editing. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF034837.1, BC137477.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2157437, SAMN03465403 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000381312.6/ ENSP00000370713.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr10:1,223,253-1,779,670 Size: 556,418 Total Exon Count: 10 Strand: -
Coding Region
   Position: hg19 chr10:1,229,133-1,779,344 Size: 550,212 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:1,223,253-1,779,670)mRNA (may differ from genome)Protein (739 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedStanford SOURCETreefamUniProtKB
Wikipedia

-  Comments and Description Text from UniProtKB
  ID: RED2_HUMAN
DESCRIPTION: RecName: Full=Double-stranded RNA-specific editase B2; EC=3.5.-.-; AltName: Full=RNA-dependent adenosine deaminase 3; AltName: Full=RNA-editing deaminase 2; AltName: Full=RNA-editing enzyme 2; AltName: Full=dsRNA adenosine deaminase B2;
FUNCTION: Does not act on glutamate receptor or on serotonin receptor subtype 2C. Capable of binding to dsRNA but also to ssRNA.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Brain specific.
SIMILARITY: Contains 1 A to I editase domain.
SIMILARITY: Contains 2 DRBM (double-stranded RNA-binding) domains.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ADARB2
CDC HuGE Published Literature: ADARB2
Positive Disease Associations: Blood Pressure Determination , Body Fat Distribution , Body Mass Index , Breath Tests , Echocardiography , Emphysema , quantitative traits , Response to radiation , Stroke
Related Studies:
  1. Blood Pressure Determination
    , , . [PubMed 0]
  2. Body Fat Distribution
    Jennifer K Lowe et al. PLoS genetics 2009, Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae., PLoS genetics. [PubMed 19197348]
  3. Body Mass Index
    Jennifer K Lowe et al. PLoS genetics 2009, Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae., PLoS genetics. [PubMed 19197348]
           more ... click here to view the complete list

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.34 RPKM in Brain - Spinal cord (cervical c-1)
Total median expression: 39.41 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -155.20326-0.476 Picture PostScript Text
3' UTR -2116.555880-0.360 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002466 - A_deamin
IPR001159 - Ds-RNA-bd
IPR014720 - dsRNA-bd-like

Pfam Domains:
PF00035 - Double-stranded RNA binding motif
PF02137 - Adenosine-deaminase (editase) domain

SCOP Domains:
54768 - dsRNA-binding domain-like

ModBase Predicted Comparative 3D Structure on Q9NS39
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
 Gene Details    
 Gene Sorter    
 RGDEnsembl   
 Protein SequenceProtein Sequence   
 AlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0003727 single-stranded RNA binding
GO:0004000 adenosine deaminase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

Biological Process:
GO:0006396 RNA processing
GO:0006397 mRNA processing

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AF034837 - Homo sapiens double-stranded RNA specific adenosine deaminase (ADAR3) mRNA, complete cds.
BC137477 - Homo sapiens adenosine deaminase, RNA-specific, B2 (RED2 homolog rat), mRNA (cDNA clone MGC:169100 IMAGE:9021477), complete cds.
BC140852 - Homo sapiens adenosine deaminase, RNA-specific, B2 (RED2 homolog rat), mRNA (cDNA clone MGC:176529 IMAGE:9021720), complete cds.
AK123334 - Homo sapiens cDNA FLJ41340 fis, clone BRASW1000125.
AK127347 - Homo sapiens cDNA FLJ45419 fis, clone BRHIP3035222.
BC047443 - Homo sapiens adenosine deaminase, RNA-specific, B2 (RED2 homolog rat), mRNA (cDNA clone IMAGE:5313608), complete cds.
AK055107 - Homo sapiens cDNA FLJ30545 fis, clone BRAWH2001418, highly similar to Double-stranded RNA-specific editase B2 (EC 3.5.-.-).
AK308579 - Homo sapiens cDNA, FLJ98620.
JD411454 - Sequence 392478 from Patent EP1572962.
AK307451 - Homo sapiens cDNA, FLJ97399.
JD394544 - Sequence 375568 from Patent EP1572962.
JD456105 - Sequence 437129 from Patent EP1572962.
JD082741 - Sequence 63765 from Patent EP1572962.
JD533567 - Sequence 514591 from Patent EP1572962.
JD241395 - Sequence 222419 from Patent EP1572962.
BC139725 - Homo sapiens adenosine deaminase, RNA-specific, B2 (RED2 homolog rat), mRNA (cDNA clone IMAGE:40001821), partial cds.
AK289895 - Homo sapiens cDNA FLJ77810 complete cds.
JD080908 - Sequence 61932 from Patent EP1572962.
JD137616 - Sequence 118640 from Patent EP1572962.
JD236336 - Sequence 217360 from Patent EP1572962.
JD554100 - Sequence 535124 from Patent EP1572962.
AK057763 - Homo sapiens cDNA FLJ25034 fis, clone CBL02804, highly similar to Homo sapiens double-stranded RNA specific adenosine deaminase (ADAR3) mRNA.
JD485598 - Sequence 466622 from Patent EP1572962.
JD423269 - Sequence 404293 from Patent EP1572962.
AK094294 - Homo sapiens cDNA FLJ36975 fis, clone BRACE2006274.
JD408006 - Sequence 389030 from Patent EP1572962.
JD468992 - Sequence 450016 from Patent EP1572962.
JD186850 - Sequence 167874 from Patent EP1572962.
JD186851 - Sequence 167875 from Patent EP1572962.
JD131323 - Sequence 112347 from Patent EP1572962.
JD522486 - Sequence 503510 from Patent EP1572962.
JD168630 - Sequence 149654 from Patent EP1572962.
JD248784 - Sequence 229808 from Patent EP1572962.
JD387567 - Sequence 368591 from Patent EP1572962.
JD177114 - Sequence 158138 from Patent EP1572962.
JD064886 - Sequence 45910 from Patent EP1572962.
JD103879 - Sequence 84903 from Patent EP1572962.
JD140938 - Sequence 121962 from Patent EP1572962.
JD462100 - Sequence 443124 from Patent EP1572962.
JD215883 - Sequence 196907 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ADAR3, B2RPJ5, NM_018702, NP_061172, Q5VUT6, Q9NS39, RED2, RED2_HUMAN
UCSC ID: uc009xhq.3
RefSeq Accession: NM_018702
Protein: Q9NS39 (aka RED2_HUMAN)
CCDS: CCDS7058.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_018702.3
exon count: 10CDS single in 3' UTR: no RNA size: 8426
ORF size: 2220CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4640.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.