Human Gene DMRTC1 (uc004ebc.3) Description and Page Index
  Description: Homo sapiens DMRT-like family C1 (DMRTC1), mRNA.
Transcript (Including UTRs)
   Position: hg19 chrX:72,091,859-72,095,622 Size: 3,764 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chrX:72,092,286-72,095,528 Size: 3,243 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Model InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chrX:72,091,859-72,095,622)mRNA (may differ from genome)Protein (192 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Doublesex- and mab-3-related transcription factor C1;
TISSUE SPECIFICITY: Predominantly expressed in kidney, pancreas, ovary and testis. Detected in brain and in many other tissues.
SIMILARITY: Belongs to the DMRT family.
CAUTION: Although related to other DMRT proteins, it does not contain a canonical DM DNA-binding domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -33.6094-0.357 Picture PostScript Text
3' UTR -126.70427-0.297 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026607 - DMRT/dsx/mab-3
IPR026606 - Dmrtc1

Pfam Domains:
PF15791 - Doublesex-and mab-3-related transcription factor C1 and C2

ModBase Predicted Comparative 3D Structure on Q5HYR2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus

-  Descriptions from all associated GenBank mRNAs
  LF211607 - JP 2014500723-A/19110: Polycomb-Associated Non-Coding RNAs.
BC029799 - Homo sapiens DMRT-like family C1B, mRNA (cDNA clone IMAGE:5196013).
BC047596 - Homo sapiens DMRT-like family C1, mRNA (cDNA clone MGC:48652 IMAGE:4830694), complete cds.
LF381877 - JP 2014500723-A/189380: Polycomb-Associated Non-Coding RNAs.
LF381872 - JP 2014500723-A/189375: Polycomb-Associated Non-Coding RNAs.
JD466567 - Sequence 447591 from Patent EP1572962.
JD262327 - Sequence 243351 from Patent EP1572962.
BC160151 - Synthetic construct Homo sapiens clone IMAGE:100064183, MGC:193266 DMRT-like family C1 (DMRTC1) mRNA, encodes complete protein.
AB527486 - Synthetic construct DNA, clone: pF1KB7925, Homo sapiens DMRTC1 gene for DMRT-like family C1, without stop codon, in Flexi system.
JD190263 - Sequence 171287 from Patent EP1572962.
JD418503 - Sequence 399527 from Patent EP1572962.
JD183541 - Sequence 164565 from Patent EP1572962.
JD074235 - Sequence 55259 from Patent EP1572962.
JD133944 - Sequence 114968 from Patent EP1572962.
JD390636 - Sequence 371660 from Patent EP1572962.
JD107152 - Sequence 88176 from Patent EP1572962.
JD279794 - Sequence 260818 from Patent EP1572962.
JD384008 - Sequence 365032 from Patent EP1572962.
LF381880 - JP 2014500723-A/189383: Polycomb-Associated Non-Coding RNAs.
LF381869 - JP 2014500723-A/189372: Polycomb-Associated Non-Coding RNAs.
CU688748 - Synthetic construct Homo sapiens gateway clone IMAGE:100017908 5' read LOC728656 mRNA.
AJ291670 - Homo sapiens partial mRNA for Doublesex-mab-3 (DM) domain, (DMRTC1 gene).
LF381882 - JP 2014500723-A/189385: Polycomb-Associated Non-Coding RNAs.
LF381867 - JP 2014500723-A/189370: Polycomb-Associated Non-Coding RNAs.
JD139349 - Sequence 120373 from Patent EP1572962.
JD056893 - Sequence 37917 from Patent EP1572962.
JD066048 - Sequence 47072 from Patent EP1572962.
JD061915 - Sequence 42939 from Patent EP1572962.
MA447184 - JP 2018138019-A/19110: Polycomb-Associated Non-Coding RNAs.
MA617454 - JP 2018138019-A/189380: Polycomb-Associated Non-Coding RNAs.
MA617449 - JP 2018138019-A/189375: Polycomb-Associated Non-Coding RNAs.
MA617457 - JP 2018138019-A/189383: Polycomb-Associated Non-Coding RNAs.
MA617446 - JP 2018138019-A/189372: Polycomb-Associated Non-Coding RNAs.
MA617459 - JP 2018138019-A/189385: Polycomb-Associated Non-Coding RNAs.
MA617444 - JP 2018138019-A/189370: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: DMRTC1B, DMRTC_HUMAN, NM_033053, NP_149042, Q5HYR0, Q5HYR2, Q5U5K2, Q8N6L3, Q96SD3
UCSC ID: uc004ebc.3
RefSeq Accession: NM_033053
Protein: Q5HYR2 (aka DMRTC_HUMAN)
CCDS: CCDS35333.2

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_033053.2
exon count: 6CDS single in 3' UTR: no RNA size: 1120
ORF size: 579CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1358.00frame shift in genome: no % Coverage: 98.21
has start codon: yes stop codon in genome: no # of Alignments: 2
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
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