Human Gene MYH15 (uc003dxa.1) Description and Page Index
  Description: Homo sapiens myosin, heavy chain 15 (MYH15), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr3:108,099,216-108,248,169 Size: 148,954 Total Exon Count: 42 Strand: -
Coding Region
   Position: hg19 chr3:108,100,392-108,248,112 Size: 147,721 Coding Exon Count: 42 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr3:108,099,216-108,248,169)mRNA (may differ from genome)Protein (1946 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
OMIMPubMedStanford SOURCETreefamUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Myosin-15; AltName: Full=Myosin heavy chain 15;
FUNCTION: Muscle contraction (By similarity).
SUBUNIT: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2) (By similarity).
SUBCELLULAR LOCATION: Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.
DOMAIN: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils (By similarity).
SIMILARITY: Contains 1 IQ domain.
SIMILARITY: Contains 1 myosin head-like domain.
CAUTION: Represents a conventional myosin. This protein should not be confused with the unconventional myosin-15 (MYO15).
SEQUENCE CAUTION: Sequence=BAA76844.3; Type=Erroneous initiation; Note=Translation N-terminally shortened;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): MYH15
CDC HuGE Published Literature: MYH15
Positive Disease Associations: Anticoagulants , Body Composition
Related Studies:
  1. Anticoagulants
    Tiphaine Oudot-Mellakh et al. British journal of haematology 2012, Genome wide association study for plasma levels of natural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA project., British journal of haematology. [PubMed 22443383]
  2. Body Composition
    , , . [PubMed 0]
  3. Body Composition
    , , . [PubMed 0]
           more ... click here to view the complete list

-  MalaCards Disease Associations
  MalaCards Gene Search: MYH15
Diseases sorted by gene-association score: autosomal recessive nonsyndromic deafness 3 (8)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.13 RPKM in Brain - Spinal cord (cervical c-1)
Total median expression: 15.51 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -1.7057-0.030 Picture PostScript Text
3' UTR -346.701176-0.295 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR015650 - Myosin_1/23/4/7/8/13/15
IPR001609 - Myosin_head_motor_dom
IPR004009 - Myosin_N
IPR002928 - Myosin_tail

Pfam Domains:
PF00063 - Myosin head (motor domain)
PF01576 - Myosin tail
PF02736 - Myosin N-terminal SH3-like domain

SCOP Domains:
50084 - Myosin S1 fragment, N-terminal domain
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on Q9Y2K3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003774 motor activity
GO:0003777 microtubule motor activity
GO:0003779 actin binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0008017 microtubule binding
GO:0051015 actin filament binding

Biological Process:
GO:0002074 extraocular skeletal muscle development
GO:0007018 microtubule-based movement

Cellular Component:
GO:0005737 cytoplasm
GO:0016459 myosin complex
GO:0030016 myofibril
GO:0032982 myosin filament

-  Descriptions from all associated GenBank mRNAs
  AB023217 - Homo sapiens KIAA1000 mRNA for KIAA1000 protein.
AK055436 - Homo sapiens cDNA FLJ30874 fis, clone FEBRA2004329, moderately similar to MYOSIN HEAVY CHAIN, CARDIAC MUSCLE ISOFORM.
BC172390 - Synthetic construct Homo sapiens clone IMAGE:100069084, MGC:199095 myosin, heavy chain 15 (MYH15) mRNA, encodes complete protein.
AB463133 - Synthetic construct DNA, clone: pF1KA1000, Homo sapiens MYH15 gene for myosin, heavy chain 15, without stop codon, in Flexi system.
AK126801 - Homo sapiens cDNA FLJ44851 fis, clone BRACE3051819, moderately similar to Myosin heavy chain, cardiac muscle alpha isoform.
JD040882 - Sequence 21906 from Patent EP1572962.
JD515131 - Sequence 496155 from Patent EP1572962.
JD328878 - Sequence 309902 from Patent EP1572962.
JD265843 - Sequence 246867 from Patent EP1572962.
JD300090 - Sequence 281114 from Patent EP1572962.
JD119609 - Sequence 100633 from Patent EP1572962.
JD162952 - Sequence 143976 from Patent EP1572962.
JD150486 - Sequence 131510 from Patent EP1572962.
JD134919 - Sequence 115943 from Patent EP1572962.
JD371525 - Sequence 352549 from Patent EP1572962.
JD484021 - Sequence 465045 from Patent EP1572962.
JD552704 - Sequence 533728 from Patent EP1572962.
JD371187 - Sequence 352211 from Patent EP1572962.
JD197422 - Sequence 178446 from Patent EP1572962.
JD250540 - Sequence 231564 from Patent EP1572962.
JD509076 - Sequence 490100 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04530 - Tight junction
hsa05416 - Viral myocarditis

-  Other Names for This Gene
  Alternate Gene Symbols: KIAA1000, MYH15_HUMAN, NM_014981, NP_055796, Q9Y2K3
UCSC ID: uc003dxa.1
RefSeq Accession: NM_014981
Protein: Q9Y2K3 (aka MYH15_HUMAN)
CCDS: CCDS43127.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_014981.1
exon count: 42CDS single in 3' UTR: no RNA size: 7074
ORF size: 5841CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 11800.50frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.