Human Gene DLEU7 (uc001vex.2) Description and Page Index
  Description: Homo sapiens deleted in lymphocytic leukemia, 7 (DLEU7), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr13:51,286,759-51,417,885 Size: 131,127 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chr13:51,287,353-51,417,782 Size: 130,430 Coding Exon Count: 2 

Page IndexSequence and LinksGenetic AssociationsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr13:51,286,759-51,417,885)mRNA (may differ from genome)Protein (160 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMGIPubMed
Stanford SOURCETreefamUniProtKB

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): DLEU7
CDC HuGE Published Literature: DLEU7
Positive Disease Associations: Amyotrophic Lateral Sclerosis , Apolipoprotein A-I , Cholesterol, HDL
Related Studies:
  1. Amyotrophic Lateral Sclerosis
    Simon Cronin et al. Human molecular genetics 2008, A genome-wide association study of sporadic ALS in a homogenous Irish population., Human molecular genetics. [PubMed 18057069]
  2. Apolipoprotein A-I
    Sekar Kathiresan et al. BMC medical genetics 2007, A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study., BMC medical genetics. [PubMed 17903299]
    Using a 100K genome-wide scan, we have generated a set of putative associations for common sequence variants and lipid phenotypes. Validation of selected hypotheses in additional samples did not identify any new loci underlying variability in blood lipids. Lack of replication may be due to inadequate statistical power to detect modest quantitative trait locus effects (i.e., <1% of trait variance explained) or reduced genomic coverage of the 100K array. GWAS in FHS using a denser genome-wide genotyping platform and a better-powered replication strategy may identify novel loci underlying blood lipids.
  3. Cholesterol, HDL
    Sekar Kathiresan et al. BMC medical genetics 2007, A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study., BMC medical genetics. [PubMed 17903299]
    Using a 100K genome-wide scan, we have generated a set of putative associations for common sequence variants and lipid phenotypes. Validation of selected hypotheses in additional samples did not identify any new loci underlying variability in blood lipids. Lack of replication may be due to inadequate statistical power to detect modest quantitative trait locus effects (i.e., <1% of trait variance explained) or reduced genomic coverage of the 100K array. GWAS in FHS using a denser genome-wide genotyping platform and a better-powered replication strategy may identify novel loci underlying blood lipids.
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-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.71 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 17.82 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -41.20103-0.400 Picture PostScript Text
3' UTR -149.74594-0.252 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF15760 - Leukemia-associated protein 7

ModBase Predicted Comparative 3D Structure on Q6UYE1-2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AK126830 - Homo sapiens cDNA FLJ44882 fis, clone BRAMY2036266.
BC112009 - Homo sapiens deleted in lymphocytic leukemia, 7, mRNA (cDNA clone MGC:138214 IMAGE:8327477), complete cds.
BC104892 - Homo sapiens deleted in lymphocytic leukemia, 7, mRNA (cDNA clone MGC:132552 IMAGE:8143895), complete cds.
KJ900465 - Synthetic construct Homo sapiens clone ccsbBroadEn_09859 DLEU7 gene, encodes complete protein.
AY357595 - Homo sapiens deleted in lymphocytic leukemia 7 (DLEU7) mRNA, complete cds.
AK303567 - Homo sapiens cDNA FLJ51434 complete cds, moderately similar to Mus musculus deleted in lymphocytic leukemia, 7 (Dleu7), mRNA.
JD056272 - Sequence 37296 from Patent EP1572962.
JD308051 - Sequence 289075 from Patent EP1572962.
JD460524 - Sequence 441548 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: LEU7, NM_198989, NP_945340, Q6UYE1-2
UCSC ID: uc001vex.2
RefSeq Accession: NM_198989
Protein: Q6UYE1-2, splice isoform of Q6UYE1 CCDS: CCDS53869.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_198989.2
exon count: 2CDS single in 3' UTR: no RNA size: 1180
ORF size: 483CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1160.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.