Human Gene OR2L13 (uc001ids.3) Description and Page Index
  Description: Homo sapiens olfactory receptor, family 2, subfamily L, member 13 (OR2L13), mRNA.
RefSeq Summary (NM_175911): Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg19 chr1:248,100,493-248,264,224 Size: 163,732 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr1:248,262,678-248,263,616 Size: 939 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:248,100,493-248,264,224)mRNA (may differ from genome)Protein (312 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMGIneXtProt
PubMedReactomeStanford SOURCETreefamUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: OR2LD_HUMAN
DESCRIPTION: RecName: Full=Olfactory receptor 2L13; AltName: Full=Olfactory receptor 2L14;
FUNCTION: Odorant receptor (Potential).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE); URL="http://bip.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR2L13";

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): OR2L13
CDC HuGE Published Literature: OR2L13
Positive Disease Associations: Erythrocyte Count , Hemoglobins
Related Studies:
  1. Erythrocyte Count
    , , . [PubMed 0]
  2. Hemoglobins
    , , . [PubMed 0]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.58 RPKM in Brain - Spinal cord (cervical c-1)
Total median expression: 19.35 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -125.60337-0.373 Picture PostScript Text
3' UTR -131.87608-0.217 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR000725 - Olfact_rcpt

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)
PF10320 - Serpentine type 7TM GPCR chemoreceptor Srsx
PF13853 - Olfactory receptor

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q8N349
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004984 olfactory receptor activity
GO:0005515 protein binding

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007608 sensory perception of smell
GO:0008150 biological_process
GO:0050896 response to stimulus
GO:0050911 detection of chemical stimulus involved in sensory perception of smell

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC028158 - Homo sapiens olfactory receptor, family 2, subfamily L, member 13, mRNA (cDNA clone MGC:40047 IMAGE:5240594), complete cds.
JD423716 - Sequence 404740 from Patent EP1572962.
CU688414 - Synthetic construct Homo sapiens gateway clone IMAGE:100020785 5' read OR2L13 mRNA.
HQ447997 - Synthetic construct Homo sapiens clone IMAGE:100071366; CCSB009556_01 olfactory receptor, family 2, subfamily L, member 13 (OR2L13) gene, encodes complete protein.
KJ895989 - Synthetic construct Homo sapiens clone ccsbBroadEn_05383 OR2L13 gene, encodes complete protein.
JD288508 - Sequence 269532 from Patent EP1572962.
JD166118 - Sequence 147142 from Patent EP1572962.
JD507431 - Sequence 488455 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04740 - Olfactory transduction

Reactome (by CSHL, EBI, and GO)

Protein Q8N349 (Reactome details) participates in the following event(s):

R-HSA-381750 Olfactory Receptor - G Protein olfactory trimer complex formation
R-HSA-381753 Olfactory Signaling Pathway
R-HSA-418555 G alpha (s) signalling events
R-HSA-388396 GPCR downstream signalling
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: NM_175911, NP_787107, OR2L14, OR2LD_HUMAN, Q5VUR5, Q8N349
UCSC ID: uc001ids.3
RefSeq Accession: NM_175911
Protein: Q8N349 (aka OR2LD_HUMAN or O2LD_HUMAN)
CCDS: CCDS1637.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_175911.2
exon count: 3CDS single in 3' UTR: no RNA size: 1913
ORF size: 939CDS single in intron: no Alignment % ID: 99.89
txCdsPredict score: 1950.00frame shift in genome: no % Coverage: 98.48
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.