Human Gene ZNF234 (uc002oyl.4)
Description: Homo sapiens zinc finger protein 234 (ZNF234), transcript variant 2, mRNA.
Transcript (Including UTRs)
Position: hg19 chr19:44,645,710-44,664,462 Size: 18,753 Total Exon Count: 6 Strand: +
Coding Region
Position: hg19 chr19:44,648,786-44,662,272 Size: 13,487 Coding Exon Count: 4
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: ZN234_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 234; AltName: Full=Zinc finger protein 269; AltName: Full=Zinc finger protein HZF4;
FUNCTION: May be involved in transcriptional regulation.SUBCELLULAR LOCATION: Nucleus (Probable).SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.SIMILARITY: Contains 19 C2H2-type zinc fingers.SIMILARITY: Contains 1 KRAB domain.
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
Common Gene Haplotype Alleles
Press "+" in the title bar above to open this section.
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
Press "+" in the title bar above to open this section.
mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd
Pfam Domains: PF00096 - Zinc finger, C2H2 type
PF01352 - KRAB box
PF12874 - Zinc-finger of C2H2 type
PF13894 - C2H2-type zinc finger
PF13912 - C2H2-type zinc finger
SCOP Domains: 48695 - Multiheme cytochromes
109640 - KRAB domain (Kruppel-associated box, Pfam 01352)
57667 - C2H2 and C2HC zinc fingers
ModBase Predicted Comparative 3D Structure on Q14588
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0046872 metal ion binding
Biological Process: GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
Cellular Component: GO:0005622 intracellular
GO:0005634 nucleus
Descriptions from all associated GenBank mRNAs
AK314064 - Homo sapiens cDNA, FLJ94730.AF228417 - Homo sapiens chromosome 19 zinc finger protein ZNF234 mRNA, partial cds.AK289843 - Homo sapiens cDNA FLJ75586 complete cds, highly similar to Homo sapiens zinc finger protein 234 (ZNF234), mRNA.BC007303 - Homo sapiens zinc finger protein 234, mRNA (cDNA clone MGC:15703 IMAGE:3352040), complete cds.JD302888 - Sequence 283912 from Patent EP1572962.X78927 - H.sapiens HZF4 mRNA for zinc finger protein.AH012544 - Homo sapiens chromosome 19 ZNF234 (ZNF234) mRNA, partial cds.AF027142 - Homo sapiens clone B7-4 zinc finger protein mRNA, partial cds.AF027143 - Homo sapiens clone B6-1 zinc finger protein mRNA, partial cds.AF027141 - Homo sapiens clone B1-8 zinc finger protein mRNA, partial cds.JD314885 - Sequence 295909 from Patent EP1572962.JD140612 - Sequence 121636 from Patent EP1572962.JD198384 - Sequence 179408 from Patent EP1572962.JD153104 - Sequence 134128 from Patent EP1572962.JD153105 - Sequence 134129 from Patent EP1572962.JD527565 - Sequence 508589 from Patent EP1572962.JD160976 - Sequence 142000 from Patent EP1572962.JD546550 - Sequence 527574 from Patent EP1572962.JD546551 - Sequence 527575 from Patent EP1572962.JD492143 - Sequence 473167 from Patent EP1572962.JD032306 - Sequence 13330 from Patent EP1572962.JD285542 - Sequence 266566 from Patent EP1572962.JD249742 - Sequence 230766 from Patent EP1572962.JD511138 - Sequence 492162 from Patent EP1572962.JD122628 - Sequence 103652 from Patent EP1572962.JD376832 - Sequence 357856 from Patent EP1572962.JD353238 - Sequence 334262 from Patent EP1572962.JD249623 - Sequence 230647 from Patent EP1572962.JD270209 - Sequence 251233 from Patent EP1572962.JD354157 - Sequence 335181 from Patent EP1572962.JD378086 - Sequence 359110 from Patent EP1572962.JD456308 - Sequence 437332 from Patent EP1572962.JD320493 - Sequence 301517 from Patent EP1572962.JD365256 - Sequence 346280 from Patent EP1572962.JD451735 - Sequence 432759 from Patent EP1572962.JD366799 - Sequence 347823 from Patent EP1572962.JD149597 - Sequence 130621 from Patent EP1572962.JD149598 - Sequence 130622 from Patent EP1572962.JD518301 - Sequence 499325 from Patent EP1572962.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: A8K1C8, NM_001144824, NP_006621, Q14588, Q96IR4, Q9NS45, Q9NYT7, ZN234_HUMAN, ZNF269UCSC ID: uc002oyl.4RefSeq Accession: NM_001144824
Protein: Q14588
(aka ZN234_HUMAN or Z234_HUMAN)
CCDS: CCDS46101.1
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_001144824.1
exon count:
6 CDS single in 3' UTR:
no
RNA size:
4482
ORF size:
2103 CDS single in intron:
no
Alignment % ID:
100.00
txCdsPredict score:
4397.00 frame shift in genome:
no
% Coverage:
100.00
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
Click here
for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
Click here
for details on how this gene model was made and data restrictions if any.