ID:SLN11_HUMAN DESCRIPTION: RecName: Full=Schlafen family member 11; FUNCTION: Interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis. Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon- usage-dependent manner. Binds to tRNAs and exploits the unique viral codon bias towards A/T nucleotides. The exact inhibition mechanism is unclear: may either sequesters tRNAs, prevents their maturation via post-transcriptional processing or accelerates their deacylation. Does not inhibit reverse transcription, integration or production and nuclear export of viral RNA. INDUCTION: By type I interferons, poly-IC and poly-dAdT. SIMILARITY: Belongs to the Schlafen family. SEQUENCE CAUTION: Sequence=BAB85010.1; Type=Frameshift; Positions=135;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q7Z7L1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0002376 immune system process GO:0006974 cellular response to DNA damage stimulus GO:0008156 negative regulation of DNA replication GO:0010942 positive regulation of cell death GO:0043111 replication fork arrest GO:0051607 defense response to virus GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
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