Description: Homo sapiens synapse defective 1, Rho GTPase, homolog 1 (C. elegans) (SYDE1), mRNA. RefSeq Summary (NM_033025): The protein encoded by this gene is a Rho GTPase-activating protein highly expressed in placenta. The encoded protein is involved in cytoskeletal remodeling and trophoblast cell migration. Decreased expression of this gene has been associated with intrauterine growth restriction (IUGR). [provided by RefSeq, Feb 2017]. Transcript (Including UTRs) Position: hg19 chr19:15,218,214-15,225,789 Size: 7,576 Total Exon Count: 8 Strand: + Coding Region Position: hg19 chr19:15,218,245-15,224,774 Size: 6,530 Coding Exon Count: 8
ID:SYDE1_HUMAN DESCRIPTION: RecName: Full=Rho GTPase-activating protein SYDE1; AltName: Full=Synapse defective protein 1 homolog 1; Short=Protein syd-1 homolog 1; FUNCTION: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity). SIMILARITY: Contains 1 Rho-GAP domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6ZW31
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0007165 signal transduction GO:0043087 regulation of GTPase activity GO:0051056 regulation of small GTPase mediated signal transduction GO:0051493 regulation of cytoskeleton organization GO:0090630 activation of GTPase activity GO:1901165 positive regulation of trophoblast cell migration
US Server
