Description: Homo sapiens transmembrane protease, serine 11D (TMPRSS11D), mRNA. RefSeq Summary (NM_004262): This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr4:68,686,594-68,749,716 Size: 63,123 Total Exon Count: 10 Strand: - Coding Region Position: hg19 chr4:68,688,055-68,749,651 Size: 61,597 Coding Exon Count: 10
ID:TM11D_HUMAN DESCRIPTION: RecName: Full=Transmembrane protease serine 11D; EC=3.4.21.-; AltName: Full=Airway trypsin-like protease; Contains: RecName: Full=Transmembrane protease serine 11D non-catalytic chain; Contains: RecName: Full=Transmembrane protease serine 11D catalytic chain; Flags: Precursor; FUNCTION: May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. CATALYTIC ACTIVITY: Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides, cleaving Boc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently and having an optimum pH of 8.6 with this substrate. ENZYME REGULATION: Strongly inhibited by diisopropyl fluorophosphate, leupeptin, antipain, aprotinin, and soybean trypsin inhibitor, but hardly inhibited by secretory leukocyte protease inhibitor at 10 microM. SUBUNIT: Monomer. SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein. Note=Activated by cleavage and secreted. SUBCELLULAR LOCATION: Transmembrane protease serine 11D catalytic chain: Secreted. Note=Activated by cleavage and secreted. TISSUE SPECIFICITY: Located in the cells of the submucosal serous glands of the bronchi and trachea. SIMILARITY: Belongs to the peptidase S1 family. SIMILARITY: Contains 1 peptidase S1 domain. SIMILARITY: Contains 1 SEA domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O60235
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
