Description: Homo sapiens processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae) (POP4), transcript variant 1, mRNA. RefSeq Summary (NM_006627): This gene encodes one of the protein subunits of the small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is localized to the nucleus and associates directly with the RNA component of these complexes. This protein is involved in processing of precursor RNAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]. Transcript (Including UTRs) Position: hg19 chr19:30,097,170-30,108,162 Size: 10,993 Total Exon Count: 7 Strand: + Coding Region Position: hg19 chr19:30,097,226-30,106,287 Size: 9,062 Coding Exon Count: 7
ID:RPP29_HUMAN DESCRIPTION: RecName: Full=Ribonuclease P protein subunit p29; Short=hPOP4; EC=3.1.26.5; FUNCTION: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. May function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P. CATALYTIC ACTIVITY: Endonucleolytic cleavage of RNA, removing 5'- extranucleotides from tRNA precursor. SUBUNIT: Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of a RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. RNase MRP consists of a RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21. Interacts with RPP25 and POP5. INTERACTION: Q99575:POP1; NbExp=2; IntAct=EBI-366477, EBI-366741; Q969H6:POP5; NbExp=2; IntAct=EBI-366477, EBI-366525; Q9BUL9:RPP25; NbExp=2; IntAct=EBI-366477, EBI-366570; P78345:RPP38; NbExp=2; IntAct=EBI-366477, EBI-366493; SUBCELLULAR LOCATION: Nucleus, nucleolus. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
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Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): POP4 CDC HuGE Published Literature: POP4 Positive Disease Associations: Inflammatory Bowel Diseases Related Studies:
Inflammatory Bowel Diseases Richard H Duerr et al. Science (New York, N.Y.) 2006, A genome-wide association study identifies IL23R as an inflammatory bowel disease gene., Science (New York, N.Y.).
[PubMed 17068223]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O95707
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
