Human Gene C1QL2 (uc002tlo.2)
  Description: Homo sapiens complement component 1, q subcomponent-like 2 (C1QL2), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr2:119,913,819-119,916,471 Size: 2,653 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chr2:119,914,378-119,915,845 Size: 1,468 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:119,913,819-119,916,471)mRNA (may differ from genome)Protein (287 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkHGNCHPRDLynxMGIneXtProt
OMIMPubMedTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: C1QL2_HUMAN
DESCRIPTION: RecName: Full=Complement C1q-like protein 2; Flags: Precursor;
FUNCTION: May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity).
SUBUNIT: Forms homotrimers which can further assemble to form higher-order oligomeric complexes (By similarity). Interacts with BAI3 (By similarity).
SUBCELLULAR LOCATION: Secreted (By similarity).
SIMILARITY: Contains 1 C1q domain.
SIMILARITY: Contains 1 collagen-like domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): C1QL2
CDC HuGE Published Literature: C1QL2
Positive Disease Associations: Lymphocytes
Related Studies:
  1. Lymphocytes
    , , . [PubMed 0]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 10.81 RPKM in Brain - Amygdala
Total median expression: 73.48 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -353.50626-0.565 Picture PostScript Text
3' UTR -212.52559-0.380 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001073 - C1q
IPR008160 - Collagen
IPR008983 - Tumour_necrosis_fac-like

Pfam Domains:
PF00386 - C1q domain
PF01391 - Collagen triple helix repeat (20 copies)

SCOP Domains:
49842 - TNF-like

ModBase Predicted Comparative 3D Structure on Q7Z5L3
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
  Protein Sequence   
  Alignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0042802 identical protein binding

Biological Process:
GO:0051259 protein oligomerization

Cellular Component:
GO:0005576 extracellular region
GO:0005581 collagen trimer


-  Descriptions from all associated GenBank mRNAs
  AF525315 - Homo sapiens C1q-domain containing protein mRNA, complete cds.
BC043189 - Homo sapiens cDNA clone IMAGE:5288321, containing frame-shift errors.
BC067896 - Homo sapiens cDNA clone IMAGE:5288177, containing frame-shift errors.
BC142965 - Homo sapiens cDNA clone IMAGE:8860385, containing frame-shift errors.
JD056184 - Sequence 37208 from Patent EP1572962.
JD393628 - Sequence 374652 from Patent EP1572962.
JD384095 - Sequence 365119 from Patent EP1572962.
JD216906 - Sequence 197930 from Patent EP1572962.
JD394187 - Sequence 375211 from Patent EP1572962.
JD111541 - Sequence 92565 from Patent EP1572962.
JD253161 - Sequence 234185 from Patent EP1572962.
JD082519 - Sequence 63543 from Patent EP1572962.
KJ905027 - Synthetic construct Homo sapiens clone ccsbBroadEn_14421 C1QL2-like gene, encodes complete protein.
JD196460 - Sequence 177484 from Patent EP1572962.
JD474832 - Sequence 455856 from Patent EP1572962.
JD336608 - Sequence 317632 from Patent EP1572962.
JD140165 - Sequence 121189 from Patent EP1572962.
JD416215 - Sequence 397239 from Patent EP1572962.
JD542148 - Sequence 523172 from Patent EP1572962.
JD123421 - Sequence 104445 from Patent EP1572962.
JD205756 - Sequence 186780 from Patent EP1572962.
JD138081 - Sequence 119105 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: C1QL2_HUMAN, NM_182528, NP_872334, Q7Z5L3
UCSC ID: uc002tlo.2
RefSeq Accession: NM_182528
Protein: Q7Z5L3 (aka C1QL2_HUMAN)
CCDS: CCDS42737.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_182528.3
exon count: 2CDS single in 3' UTR: no RNA size: 2049
ORF size: 864CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1758.50frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.