Description: Homo sapiens autophagy related 5 (ATG5), mRNA. RefSeq Summary (NM_004849): The protein encoded by this gene, in combination with autophagy protein 12, functions as an E1-like activating enzyme in a ubiquitin-like conjugating system. The encoded protein is involved in several cellular processes, including autophagic vesicle formation, mitochondrial quality control after oxidative damage, negative regulation of the innate antiviral immune response, lymphocyte development and proliferation, MHC II antigen presentation, adipocyte differentiation, and apoptosis. Several transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2015]. Transcript (Including UTRs) Position: hg19 chr6:106,632,352-106,773,695 Size: 141,344 Total Exon Count: 8 Strand: - Coding Region Position: hg19 chr6:106,634,415-106,764,083 Size: 129,669 Coding Exon Count: 7
ID:ATG5_HUMAN DESCRIPTION: RecName: Full=Autophagy protein 5; AltName: Full=APG5-like; AltName: Full=Apoptosis-specific protein; FUNCTION: Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed (By similarity). FUNCTION: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. SUBUNIT: The ATG5-ATG12 conjugate forms a complex with several units of ATG16. Interacts with TECPR1; the interaction is direct and does not take place when ATG16 is associated with the ATG5- ATG12 conjugate. INTERACTION: O95166:GABARAP; NbExp=2; IntAct=EBI-1047414, EBI-712001; Q9GZQ8:MAP1LC3B; NbExp=2; IntAct=EBI-1047414, EBI-373144; Q7Z6L1:TECPR1; NbExp=6; IntAct=EBI-1047414, EBI-2946676; Q8IZQ1:WDFY3; NbExp=6; IntAct=EBI-1047414, EBI-1569256; SUBCELLULAR LOCATION: Cytoplasm. Note=Colocalizes with nonmuscle actin. TISSUE SPECIFICITY: Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells. INDUCTION: By apoptotic stimuli. PTM: Conjugated to ATG12; which is essential for autophagy, but is not required for association with isolation membrane. SIMILARITY: Belongs to the ATG5 family.
Atrial Natriuretic Factor Emelia J Benjamin et al. BMC medical genetics 2007, Genome-wide association with select biomarker traits in the Framingham Heart Study., BMC medical genetics.
[PubMed 17903293]
The Framingham GWAS represents a resource to describe potentially novel genetic influences on systemic biomarker variability. The newly described associations will need to be replicated in other studies.
Atrial Natriuretic Factor Emelia J Benjamin et al. BMC medical genetics 2007, Genome-wide association with select biomarker traits in the Framingham Heart Study., BMC medical genetics.
[PubMed 17903293]
The Framingham GWAS represents a resource to describe potentially novel genetic influences on systemic biomarker variability. The newly described associations will need to be replicated in other studies.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H1Y0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000045 autophagosome assembly GO:0000422 mitophagy GO:0001974 blood vessel remodeling GO:0002376 immune system process GO:0002739 regulation of cytokine secretion involved in immune response GO:0006501 C-terminal protein lipidation GO:0006914 autophagy GO:0006915 apoptotic process GO:0006995 cellular response to nitrogen starvation GO:0009267 cellular response to starvation GO:0009620 response to fungus GO:0016236 macroautophagy GO:0019725 cellular homeostasis GO:0019883 antigen processing and presentation of endogenous antigen GO:0031397 negative regulation of protein ubiquitination GO:0035973 aggrephagy GO:0039689 negative stranded viral RNA replication GO:0042311 vasodilation GO:0042493 response to drug GO:0043066 negative regulation of apoptotic process GO:0043687 post-translational protein modification GO:0044804 nucleophagy GO:0045060 negative thymic T cell selection GO:0048840 otolith development GO:0050765 negative regulation of phagocytosis GO:0051279 regulation of release of sequestered calcium ion into cytosol GO:0055015 ventricular cardiac muscle cell development GO:0060047 heart contraction GO:0060548 negative regulation of cell death GO:0061739 protein lipidation involved in autophagosome assembly GO:0070257 positive regulation of mucus secretion GO:0071500 cellular response to nitrosative stress GO:0075044 autophagy of host cells involved in interaction with symbiont GO:1902017 regulation of cilium assembly GO:2000377 regulation of reactive oxygen species metabolic process GO:2000378 negative regulation of reactive oxygen species metabolic process GO:2000619 negative regulation of histone H4-K16 acetylation
US Server
