Description: Homo sapiens autophagy related 12 (ATG12), transcript variant 1, mRNA. RefSeq Summary (NM_004707): Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG12 is the human homolog of a yeast protein involved in autophagy (Mizushima et al., 1998 [PubMed 9852036]).[supplied by OMIM, Mar 2008]. Transcript (Including UTRs) Position: hg19 chr5:115,163,894-115,177,548 Size: 13,655 Total Exon Count: 4 Strand: - Coding Region Position: hg19 chr5:115,167,501-115,177,249 Size: 9,749 Coding Exon Count: 4
ID:ATG12_HUMAN DESCRIPTION: RecName: Full=Ubiquitin-like protein ATG12; AltName: Full=Autophagy-related protein 12; Short=APG12-like; FUNCTION: Ubiquitin-like protein required for autophagy. Conjugated to ATG3 and ATG5. SUBCELLULAR LOCATION: Cytoplasm (By similarity). TISSUE SPECIFICITY: Ubiquitous. DOMAIN: Shares weak sequence similarity with ubiquitin family, but contains an 'ubiquitin superfold' and the C-terminal Gly is required for isopeptide linkage. SIMILARITY: Belongs to the ATG12 family. SEQUENCE CAUTION: Sequence=AAH12266.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O94817
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
