Human Gene CCDC105 (uc002nae.2)
  Description: Homo sapiens coiled-coil domain containing 105 (CCDC105), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr19:15,121,539-15,134,083 Size: 12,545 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr19:15,121,638-15,133,931 Size: 12,294 Coding Exon Count: 7 

Page IndexSequence and LinksPrimersGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:15,121,539-15,134,083)mRNA (may differ from genome)Protein (499 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtPubMedTreefamUniProtKBBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): CCDC105
CDC HuGE Published Literature: CCDC105
Positive Disease Associations: Blood Pressure
Related Studies:
  1. Blood Pressure
    , , . [PubMed 0]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 15.73 RPKM in Testis
Total median expression: 15.75 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -32.3099-0.326 Picture PostScript Text
3' UTR -47.90152-0.315 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000435 - Tektin

Pfam Domains:
PF03148 - Tektin family

ModBase Predicted Comparative 3D Structure on Q8IYK2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
 Protein SequenceProtein Sequence   
 AlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  AK097684 - Homo sapiens cDNA FLJ40365 fis, clone TESTI2034774.
BC035678 - Homo sapiens coiled-coil domain containing 105, mRNA (cDNA clone MGC:46232 IMAGE:5742752), complete cds.
JD209495 - Sequence 190519 from Patent EP1572962.
KJ904975 - Synthetic construct Homo sapiens clone ccsbBroadEn_14369 CCDC105-like gene, encodes complete protein.
AL833847 - Homo sapiens mRNA; cDNA DKFZp434H1536 (from clone DKFZp434H1536).
JD442250 - Sequence 423274 from Patent EP1572962.
JD355562 - Sequence 336586 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: CC105_HUMAN, NM_173482, NP_775753, Q8IYK2, Q8N7T5, Q8NDL5
UCSC ID: uc002nae.2
RefSeq Accession: NM_173482
Protein: Q8IYK2 (aka CC105_HUMAN)
CCDS: CCDS12322.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_173482.2
exon count: 7CDS single in 3' UTR: no RNA size: 1751
ORF size: 1500CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2375.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.