To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): STX4 CDC HuGE Published Literature: STX4 Positive Disease Associations: Warfarin Related Studies:
Warfarin Gregory M Cooper et al. Blood 2008, A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose., Blood.
[PubMed 18535201]
common SNPs with large effects on warfarin dose are unlikely to be discovered outside of the CYP2C9 and VKORC1 genes.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on A8MXY0
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK091833 - Homo sapiens cDNA FLJ34514 fis, clone HLUNG2006599, highly similar to Syntaxin-4. AX747209 - Sequence 734 from Patent EP1308459. AK315716 - Homo sapiens cDNA, FLJ96817, Homo sapiens syntaxin 4A (placental) (STX4A), mRNA. AK296652 - Homo sapiens cDNA FLJ57517 complete cds, highly similar to Syntaxin-4. BC002436 - Homo sapiens syntaxin 4, mRNA (cDNA clone MGC:1480 IMAGE:3345863), complete cds. AF318489 - Homo sapiens syntaxin 4 (STX4) precursor RNA, complete cds. U07158 - Human syntaxin mRNA, complete cds. KJ892223 - Synthetic construct Homo sapiens clone ccsbBroadEn_01617 STX4 gene, encodes complete protein. AB464273 - Synthetic construct DNA, clone: pF1KB8238, Homo sapiens STX4 gene for syntaxin 4, without stop codon, in Flexi system. BT007326 - Homo sapiens syntaxin 4A (placental) mRNA, complete cds. AF026007 - Homo sapiens syntaxin 4 (STX4) mRNA, complete cds. AJ000541 - Homo sapiens mRNA for syntaxin 4 precursor. CR541806 - Homo sapiens full open reading frame cDNA clone RZPDo834F0631D for gene STX4A, syntaxin 4A (placental); complete cds, incl. stopcodon. X85784 - H.sapiens mRNA for syntaxin 4. JD146077 - Sequence 127101 from Patent EP1572962. JD054096 - Sequence 35120 from Patent EP1572962. JD389141 - Sequence 370165 from Patent EP1572962. JD375313 - Sequence 356337 from Patent EP1572962. JD276244 - Sequence 257268 from Patent EP1572962. JD544681 - Sequence 525705 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04130 - SNARE interactions in vesicular transport hsa04962 - Vasopressin-regulated water reabsorption