Description: Homo sapiens FAST kinase domains 3 (FASTKD3), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA. RefSeq Summary (NM_024091): This gene encodes a member of a small family of Fas-activated serine/threonine kinase domain (FASTKD) containing proteins that share an amino terminal mitochondrial targeting domain and multiple carboxy terminal FAST domains as well as a putative RNA-binding RAP domain. The members of this family are ubiquitously expressed and are generally most abundant in mitochondria-enriched tissues such as heart, skeletal muscle and brown-adipose tissue. Some members of this protein family may play a role in apoptosis. The protein encoded by this gene interacts with components of the mitochondrial respiratory and translation networks. A pseudogene of this gene is also present on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]. Transcript (Including UTRs) Position: hg19 chr5:7,859,272-7,869,150 Size: 9,879 Total Exon Count: 7 Strand: - Coding Region Position: hg19 chr5:7,859,548-7,868,196 Size: 8,649 Coding Exon Count: 6
ID:FAKD3_HUMAN DESCRIPTION: RecName: Full=FAST kinase domain-containing protein 3; SIMILARITY: Belongs to the FAST kinase family. SIMILARITY: Contains 1 RAP domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF06743 - FAST kinase-like protein, subdomain 1 PF08368 - FAST kinase-like protein, subdomain 2 PF08373 - RAP domain
ModBase Predicted Comparative 3D Structure on Q14CZ7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
