Human Gene BTNL3 (uc003mmr.3)
  Description: Homo sapiens butyrophilin-like 3 (BTNL3), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr5:180,415,845-180,433,727 Size: 17,883 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg19 chr5:180,416,029-180,432,872 Size: 16,844 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:180,415,845-180,433,727)mRNA (may differ from genome)Protein (466 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGeneCardsGeneNetworkH-INV
HGNCHPRDLynxMGIneXtProtOMIM
PubMedTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: BTNL3_HUMAN
DESCRIPTION: RecName: Full=Butyrophilin-like protein 3; AltName: Full=Butyrophilin-like receptor; Flags: Precursor;
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (By similarity).
TISSUE SPECIFICITY: Expressed in small intestine, colon, testis, spleen, and leukocyte.
SIMILARITY: Belongs to the immunoglobulin superfamily. BTN/MOG family.
SIMILARITY: Contains 1 B30.2/SPRY domain.
SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 41.90 RPKM in Small Intestine - Terminal Ileum
Total median expression: 64.39 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -47.17184-0.256 Picture PostScript Text
3' UTR -236.30855-0.276 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001870 - B30.2/SPRY
IPR003879 - Butyrophylin
IPR008985 - ConA-like_lec_gl_sf
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR003599 - Ig_sub
IPR013106 - Ig_V-set
IPR006574 - PRY
IPR018355 - SPla/RYanodine_receptor_subgr
IPR003877 - SPRY_rcpt

Pfam Domains:
PF00622 - SPRY domain
PF07686 - Immunoglobulin V-set domain
PF13765 - SPRY-associated domain

SCOP Domains:
48726 - Immunoglobulin

ModBase Predicted Comparative 3D Structure on Q6UXE8
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
 Gene Details    
 Gene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function

Biological Process:
GO:0008150 biological_process

Cellular Component:
GO:0005575 cellular_component
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK025267 - Homo sapiens cDNA: FLJ21614 fis, clone COL07391, highly similar to AB020625 Homo sapiens mRNA for butyrophilin like receptor.
AB020625 - Homo sapiens mRNA for butyrophilin like receptor, complete cds.
JD087583 - Sequence 68607 from Patent EP1572962.
AY358385 - Homo sapiens clone DNA68866 BTNL3 (UNQ744) mRNA, complete cds.
BC100800 - Homo sapiens butyrophilin-like 3, mRNA (cDNA clone MGC:118823 IMAGE:40000697), complete cds.
BC100801 - Homo sapiens butyrophilin-like 3, mRNA (cDNA clone MGC:118824 IMAGE:40000698), complete cds.
BC100802 - Homo sapiens butyrophilin-like 3, mRNA (cDNA clone MGC:118825 IMAGE:40000699), complete cds.
JD084990 - Sequence 66014 from Patent EP1572962.
KJ898308 - Synthetic construct Homo sapiens clone ccsbBroadEn_07702 BTNL3 gene, encodes complete protein.
KJ898309 - Synthetic construct Homo sapiens clone ccsbBroadEn_07703 BTNL3 gene, encodes complete protein.
JD436131 - Sequence 417155 from Patent EP1572962.
JD124477 - Sequence 105501 from Patent EP1572962.
JD037335 - Sequence 18359 from Patent EP1572962.
JD528932 - Sequence 509956 from Patent EP1572962.
JD255178 - Sequence 236202 from Patent EP1572962.
JD085174 - Sequence 66198 from Patent EP1572962.
MP113331 - Sequence 2 from Patent WO2019053272.

-  Other Names for This Gene
  Alternate Gene Symbols: BTNL3_HUMAN, BTNLR, COLF4100, NM_197975, NP_932079, Q496L7, Q6UXE8, Q9Y2C7, UNQ744/PRO1472
UCSC ID: uc003mmr.3
RefSeq Accession: NM_197975
Protein: Q6UXE8 (aka BTNL3_HUMAN)
CCDS: CCDS47358.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_197975.2
exon count: 8CDS single in 3' UTR: no RNA size: 2454
ORF size: 1401CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2862.00frame shift in genome: no % Coverage: 99.43
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.