Human Gene BTNL3 (uc003mmr.3)
Description: Homo sapiens butyrophilin-like 3 (BTNL3), mRNA.
Transcript (Including UTRs)
Position: hg19 chr5:180,415,845-180,433,727 Size: 17,883 Total Exon Count: 8 Strand: +
Coding Region
Position: hg19 chr5:180,416,029-180,432,872 Size: 16,844 Coding Exon Count: 8
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: BTNL3_HUMAN
DESCRIPTION: RecName: Full=Butyrophilin-like protein 3; AltName: Full=Butyrophilin-like receptor; Flags: Precursor;
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (By similarity).TISSUE SPECIFICITY: Expressed in small intestine, colon, testis, spleen, and leukocyte.SIMILARITY: Belongs to the immunoglobulin superfamily. BTN/MOG family.SIMILARITY: Contains 1 B30.2/SPRY domain.SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR001870 - B30.2/SPRY
IPR003879 - Butyrophylin
IPR008985 - ConA-like_lec_gl_sf
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR003599 - Ig_sub
IPR013106 - Ig_V-set
IPR006574 - PRY
IPR018355 - SPla/RYanodine_receptor_subgr
IPR003877 - SPRY_rcpt
Pfam Domains: PF00622 - SPRY domain
PF07686 - Immunoglobulin V-set domain
PF13765 - SPRY-associated domain
SCOP Domains: 48726 - Immunoglobulin
ModBase Predicted Comparative 3D Structure on Q6UXE8
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AK025267 - Homo sapiens cDNA: FLJ21614 fis, clone COL07391, highly similar to AB020625 Homo sapiens mRNA for butyrophilin like receptor.AB020625 - Homo sapiens mRNA for butyrophilin like receptor, complete cds.JD087583 - Sequence 68607 from Patent EP1572962.AY358385 - Homo sapiens clone DNA68866 BTNL3 (UNQ744) mRNA, complete cds.BC100800 - Homo sapiens butyrophilin-like 3, mRNA (cDNA clone MGC:118823 IMAGE:40000697), complete cds.BC100801 - Homo sapiens butyrophilin-like 3, mRNA (cDNA clone MGC:118824 IMAGE:40000698), complete cds.BC100802 - Homo sapiens butyrophilin-like 3, mRNA (cDNA clone MGC:118825 IMAGE:40000699), complete cds.JD084990 - Sequence 66014 from Patent EP1572962.KJ898308 - Synthetic construct Homo sapiens clone ccsbBroadEn_07702 BTNL3 gene, encodes complete protein.KJ898309 - Synthetic construct Homo sapiens clone ccsbBroadEn_07703 BTNL3 gene, encodes complete protein.JD436131 - Sequence 417155 from Patent EP1572962.JD124477 - Sequence 105501 from Patent EP1572962.JD037335 - Sequence 18359 from Patent EP1572962.JD528932 - Sequence 509956 from Patent EP1572962.JD255178 - Sequence 236202 from Patent EP1572962.JD085174 - Sequence 66198 from Patent EP1572962.MP113331 - Sequence 2 from Patent WO2019053272.
Other Names for This Gene
Alternate Gene Symbols: BTNL3_HUMAN, BTNLR, COLF4100, NM_197975, NP_932079, Q496L7, Q6UXE8, Q9Y2C7, UNQ744/PRO1472UCSC ID: uc003mmr.3RefSeq Accession: NM_197975
Protein: Q6UXE8
(aka BTNL3_HUMAN)
CCDS: CCDS47358.1
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_197975.2
exon count:
8 CDS single in 3' UTR:
no
RNA size:
2454
ORF size:
1401 CDS single in intron:
no
Alignment % ID:
100.00
txCdsPredict score:
2862.00 frame shift in genome:
no
% Coverage:
99.43
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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