Description: Homo sapiens mediator complex subunit 4 (MED4), transcript variant 1, mRNA. RefSeq Summary (NM_014166): This gene encodes a component of the Mediator complex. The Mediator complex interacts with DNA-binding gene-specific transcription factors to modulate transcription by RNA polymerase II. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]. Transcript (Including UTRs) Position: hg19 chr13:48,649,864-48,669,277 Size: 19,414 Total Exon Count: 7 Strand: - Coding Region Position: hg19 chr13:48,651,275-48,669,214 Size: 17,940 Coding Exon Count: 7
ID:MED4_HUMAN DESCRIPTION: RecName: Full=Mediator of RNA polymerase II transcription subunit 4; AltName: Full=Activator-recruited cofactor 36 kDa component; Short=ARC36; AltName: Full=Mediator complex subunit 4; AltName: Full=TRAP/SMCC/PC2 subunit p36 subunit; AltName: Full=Vitamin D3 receptor-interacting protein complex 36 kDa component; Short=DRIP36; FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. SUBUNIT: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. INTERACTION: Q9NWA0:MED9; NbExp=8; IntAct=EBI-394607, EBI-394653; SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the Mediator complex subunit 4 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NPJ6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
