Human Gene TM9SF4 (uc002wxj.2)
Description: Homo sapiens transmembrane 9 superfamily protein member 4 (TM9SF4), mRNA.
Transcript (Including UTRs)
Position: hg19 chr20:30,697,309-30,755,061 Size: 57,753 Total Exon Count: 18 Strand: +
Coding Region
Position: hg19 chr20:30,697,544-30,753,247 Size: 55,704 Coding Exon Count: 18
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: TM9S4_HUMAN
DESCRIPTION: RecName: Full=Transmembrane 9 superfamily member 4; Flags: Precursor;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Probable).SIMILARITY: Belongs to the nonaspanin (TM9SF) family.SEQUENCE CAUTION: Sequence=AAH21107.1; Type=Erroneous initiation; Sequence=BAA13385.2; Type=Erroneous initiation;
Primer design for this transcript
MalaCards Disease Associations
MalaCards Gene Search: TM9SF4
Diseases sorted by gene-association score: melanoma (3)
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR004240 - EMP70
Pfam Domains: PF02990 - Endomembrane protein 70
ModBase Predicted Comparative 3D Structure on Q92544
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AK294980 - Homo sapiens cDNA FLJ54092 complete cds, highly similar to Transmembrane 9 superfamily protein member 4.AK126534 - Homo sapiens cDNA FLJ44570 fis, clone UTERU3011063, highly similar to Transmembrane 9 superfamily protein member 4.AK302439 - Homo sapiens cDNA FLJ54711 complete cds, highly similar to Transmembrane 9 superfamily protein member 4.AK296500 - Homo sapiens cDNA FLJ53349 complete cds, highly similar to Transmembrane 9 superfamily protein member 4.BC021107 - Homo sapiens transmembrane 9 superfamily protein member 4, mRNA (cDNA clone MGC:31858 IMAGE:4896167), complete cds.D87444 - Homo sapiens mRNA for KIAA0255 gene, partial cds.BC005173 - Homo sapiens cDNA clone IMAGE:3507918, containing frame-shift errors.BC022850 - Homo sapiens transmembrane 9 superfamily protein member 4, mRNA (cDNA clone IMAGE:4098679), partial cds.AB527227 - Synthetic construct DNA, clone: pF1KA0255, Homo sapiens TM9SF4 gene for transmembrane 9 superfamily protein member 4, without stop codon, in Flexi system.AK316293 - Homo sapiens cDNA, FLJ79192 complete cds, highly similar to Transmembrane 9 superfamily protein member 4.AK124411 - Homo sapiens cDNA FLJ42420 fis, clone BLADE2002730.JD559948 - Sequence 540972 from Patent EP1572962.JD485120 - Sequence 466144 from Patent EP1572962.JD538920 - Sequence 519944 from Patent EP1572962.JD312651 - Sequence 293675 from Patent EP1572962.JD368194 - Sequence 349218 from Patent EP1572962.JD228347 - Sequence 209371 from Patent EP1572962.JD496150 - Sequence 477174 from Patent EP1572962.JD457773 - Sequence 438797 from Patent EP1572962.JD360862 - Sequence 341886 from Patent EP1572962.JD230171 - Sequence 211195 from Patent EP1572962.JD132919 - Sequence 113943 from Patent EP1572962.JD166857 - Sequence 147881 from Patent EP1572962.JD519560 - Sequence 500584 from Patent EP1572962.JD164641 - Sequence 145665 from Patent EP1572962.JD105137 - Sequence 86161 from Patent EP1572962.JD513327 - Sequence 494351 from Patent EP1572962.JD068560 - Sequence 49584 from Patent EP1572962.JD103869 - Sequence 84893 from Patent EP1572962.JD049677 - Sequence 30701 from Patent EP1572962.JD073672 - Sequence 54696 from Patent EP1572962.JD062243 - Sequence 43267 from Patent EP1572962.JD330431 - Sequence 311455 from Patent EP1572962.JD101686 - Sequence 82710 from Patent EP1572962.JD324955 - Sequence 305979 from Patent EP1572962.JD369383 - Sequence 350407 from Patent EP1572962.JD455361 - Sequence 436385 from Patent EP1572962.JD416739 - Sequence 397763 from Patent EP1572962.JD190290 - Sequence 171314 from Patent EP1572962.JD124119 - Sequence 105143 from Patent EP1572962.JD511281 - Sequence 492305 from Patent EP1572962.JD055374 - Sequence 36398 from Patent EP1572962.JD053920 - Sequence 34944 from Patent EP1572962.JD364788 - Sequence 345812 from Patent EP1572962.JD513678 - Sequence 494702 from Patent EP1572962.JD320093 - Sequence 301117 from Patent EP1572962.JD566707 - Sequence 547731 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: B0QYT7, KIAA0255, NM_014742, NP_055557, Q92544, Q9NUA3, TM9S4_HUMANUCSC ID: uc002wxj.2RefSeq Accession: NM_014742
Protein: Q92544
(aka TM9S4_HUMAN or T9S4_HUMAN)
CCDS: CCDS13196.2
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_014742.3
exon count:
18 CDS single in 3' UTR:
no
RNA size:
3996
ORF size:
1929 CDS single in intron:
no
Alignment % ID:
100.00
txCdsPredict score:
4019.00 frame shift in genome:
no
% Coverage:
99.55
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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