Description: Homo sapiens metallothionein 1B (MT1B), mRNA. RefSeq Summary (NM_005947): The protein encoded by this gene binds heavy metals and protects against toxicity from heavy metal ions. This gene is found in a cluster of similar genes on chromosome 16. [provided by RefSeq, Jul 2016]. Transcript (Including UTRs) Position: hg19 chr16:56,685,811-56,687,116 Size: 1,306 Total Exon Count: 3 Strand: + Coding Region Position: hg19 chr16:56,685,866-56,686,977 Size: 1,112 Coding Exon Count: 3
ID:MT1B_HUMAN DESCRIPTION: RecName: Full=Metallothionein-1B; Short=MT-1B; AltName: Full=Metallothionein-IB; Short=MT-IB; FUNCTION: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. SUBUNIT: Monomer. DOMAIN: Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines. SIMILARITY: Belongs to the metallothionein superfamily. Type 1 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P07438
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
