Human Gene C8orf76 (uc003yqc.2)
  Description: Homo sapiens chromosome 8 open reading frame 76 (C8orf76), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr8:124,232,196-124,253,638 Size: 21,443 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr8:124,232,343-124,253,586 Size: 21,244 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:124,232,196-124,253,638)mRNA (may differ from genome)Protein (380 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMGIneXtProt
PubMedTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CH076_HUMAN
DESCRIPTION: RecName: Full=Uncharacterized protein C8orf76;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): C8orf76
CDC HuGE Published Literature: C8orf76

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.40 RPKM in Pituitary
Total median expression: 198.29 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -22.4052-0.431 Picture PostScript Text
3' UTR -21.60147-0.147 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011990 - TPR-like_helical

SCOP Domains:
81901 - HCP-like
48439 - Protein prenylyltransferase
48452 - TPR-like

ModBase Predicted Comparative 3D Structure on Q96K31
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
 Protein SequenceProtein Sequence   
 AlignmentAlignment   

-  Descriptions from all associated GenBank mRNAs
  BC012379 - Homo sapiens chromosome 8 open reading frame 76, mRNA (cDNA clone MGC:9784 IMAGE:3857253), complete cds.
KJ903490 - Synthetic construct Homo sapiens clone ccsbBroadEn_12884 C8orf76 gene, encodes complete protein.
BC067796 - Homo sapiens chromosome 8 open reading frame 76, mRNA (cDNA clone MGC:87230 IMAGE:5260773), complete cds.
AK222660 - Homo sapiens mRNA for hypothetical protein FLJ14825 variant, clone: CBL08521.
AK055796 - Homo sapiens cDNA FLJ31234 fis, clone KIDNE2004626.
AK027731 - Homo sapiens cDNA FLJ14825 fis, clone OVARC1000781.
JD224770 - Sequence 205794 from Patent EP1572962.
GQ129275 - Synthetic construct Homo sapiens clone HAIB:100068669; DKFZo004C0736 chromosome 8 open reading frame 76 protein (C8orf76) gene, partial cds.
GQ129276 - Synthetic construct Homo sapiens clone HAIB:100068572; DKFZo008C0735 chromosome 8 open reading frame 76 protein (C8orf76) gene, complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: CH076_HUMAN, NM_032847, NP_116236, Q53HC1, Q96K31
UCSC ID: uc003yqc.2
RefSeq Accession: NM_032847
Protein: Q96K31 (aka CH076_HUMAN)
CCDS: CCDS6341.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_032847.2
exon count: 6CDS single in 3' UTR: no RNA size: 1351
ORF size: 1143CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2486.00frame shift in genome: no % Coverage: 99.33
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.