Human Gene TMEM187 (uc004fjq.2)
  Description: Homo sapiens transmembrane protein 187 (TMEM187), mRNA.
RefSeq Summary (NM_003492): This gene consists of two exons and encodes a multi-pass membrane protein. An alternatively spliced transcript variant encoding the same protein has been found, but its biological validity is not determined. [provided by RefSeq, May 2010].
Transcript (Including UTRs)
   Position: hg19 chrX:153,237,991-153,248,646 Size: 10,656 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chrX:153,247,514-153,248,299 Size: 786 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:153,237,991-153,248,646)mRNA (may differ from genome)Protein (261 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMGIneXtProt
OMIMPubMedTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TM187_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 187; AltName: Full=Protein ITBA1;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
TISSUE SPECIFICITY: Ubiquitous.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.97 RPKM in Adrenal Gland
Total median expression: 202.97 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -248.90534-0.466 Picture PostScript Text
3' UTR -111.20347-0.320 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF15100 - TMEM187 protein family

ModBase Predicted Comparative 3D Structure on Q14656
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function

Biological Process:
GO:0008150 biological_process

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030133 transport vesicle


-  Descriptions from all associated GenBank mRNAs
  DQ655925 - Homo sapiens clone UGL3c12, mRNA sequence.
AK314938 - Homo sapiens cDNA, FLJ95849.
X92475 - H.sapiens mRNA for ITBA1 protein.
BC008203 - Homo sapiens transmembrane protein 187, mRNA (cDNA clone MGC:17711 IMAGE:3868838), complete cds.
BC017026 - Homo sapiens transmembrane protein 187, mRNA (cDNA clone MGC:9043 IMAGE:3847234), complete cds.
JD083740 - Sequence 64764 from Patent EP1572962.
JD190255 - Sequence 171279 from Patent EP1572962.
JD047228 - Sequence 28252 from Patent EP1572962.
JD482830 - Sequence 463854 from Patent EP1572962.
JD414330 - Sequence 395354 from Patent EP1572962.
JD513840 - Sequence 494864 from Patent EP1572962.
JD491378 - Sequence 472402 from Patent EP1572962.
AM393452 - Synthetic construct Homo sapiens clone IMAGE:100002056 for hypothetical protein (CXorf12 gene).
AB528750 - Synthetic construct DNA, clone: pF1KE0133, Homo sapiens TMEM187 gene for transmembrane protein 187, without stop codon, in Flexi system.
CR457047 - Homo sapiens full open reading frame cDNA clone RZPDo834A0615D for gene CXorf12, chromosome X open reading frame 12; complete cds, incl. stopcodon.
CU677803 - Synthetic construct Homo sapiens gateway clone IMAGE:100018654 5' read TMEM187 mRNA.
KJ892485 - Synthetic construct Homo sapiens clone ccsbBroadEn_01879 TMEM187 gene, encodes complete protein.
JD128260 - Sequence 109284 from Patent EP1572962.
JD557232 - Sequence 538256 from Patent EP1572962.
JD289356 - Sequence 270380 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B2RC47, CXorf12, DXS9878E, ITBA1, NM_003492, NP_003483, Q14656, Q6IAV7, TM187_HUMAN
UCSC ID: uc004fjq.2
RefSeq Accession: NM_003492
Protein: Q14656 (aka TM187_HUMAN)
CCDS: CCDS14739.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_003492.2
exon count: 2CDS single in 3' UTR: no RNA size: 1682
ORF size: 786CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1172.00frame shift in genome: no % Coverage: 99.11
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.