Description: Homo sapiens hexamethylene bis-acetamide inducible 1 (HEXIM1), mRNA. RefSeq Summary (NM_006460): Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Transcript (Including UTRs) Position: hg19 chr17:43,224,684-43,229,468 Size: 4,785 Total Exon Count: 1 Strand: + Coding Region Position: hg19 chr17:43,226,558-43,227,637 Size: 1,080 Coding Exon Count: 1
ID:HEXI1_HUMAN DESCRIPTION: RecName: Full=Protein HEXIM1; AltName: Full=Cardiac lineage protein 1; AltName: Full=Estrogen down-regulated gene 1 protein; AltName: Full=Hexamethylene bis-acetamide-inducible protein 1; AltName: Full=Menage a quatre protein 1; FUNCTION: Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity. SUBUNIT: Homooligomer and heterooligomer with HEXIM2; probably dimeric. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Interacts with the N-CoR complex through NCOR1. Interacts with ESR1 and NR3C1. May interact with NF-kappa-B through RELA. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Binds alpha- importin and is mostly nuclear. TISSUE SPECIFICITY: Ubiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed. Expressed in endocrine tissues. INDUCTION: Up-regulated by HMBA (hexamethylene bisacetamide) (at protein level). Down-regulated by estrogen. DOMAIN: The coiled-coil domain mediates oligomerization. MISCELLANEOUS: Inhibits Tat activity which is required for HIV-1 transcription. SIMILARITY: Belongs to the HEXIM family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O94992
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0005515 protein binding GO:0017069 snRNA binding GO:0097322 7SK snRNA binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0002218 activation of innate immune response GO:0002376 immune system process GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0007507 heart development GO:0045087 innate immune response GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045892 negative regulation of transcription, DNA-templated GO:1901798 positive regulation of signal transduction by p53 class mediator
US Server
