Description: Homo sapiens TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa (TAF2), mRNA. RefSeq Summary (NM_003184): Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that is stably associated with the TFIID complex. It contributes to interactions at and downstream of the transcription initiation site, interactions that help determine transcription complex response to activators. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr8:120,743,014-120,845,074 Size: 102,061 Total Exon Count: 26 Strand: - Coding Region Position: hg19 chr8:120,744,164-120,844,804 Size: 100,641 Coding Exon Count: 26
ID:TAF2_HUMAN DESCRIPTION: RecName: Full=Transcription initiation factor TFIID subunit 2; AltName: Full=150 kDa cofactor of initiator function; AltName: Full=RNA polymerase II TBP-associated factor subunit B; AltName: Full=TBP-associated factor 150 kDa; AltName: Full=Transcription initiation factor TFIID 150 kDa subunit; Short=TAF(II)150; Short=TAFII-150; Short=TAFII150; FUNCTION: Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. It requires core promoter-specific cofactors for productive transcription stimulation. TAF2 stabilizes TFIID binding to core promoter. SUBUNIT: Component of transcription factor TFIID which is composed of TBP and a number of TBP-associated factors. Interacts with TAF2C1. Component of the TFTC-HAT complex. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Expressed in all tissues tested. MISCELLANEOUS: PubMed:9418870 was unable to show an association between TAF2 and TFIID. SIMILARITY: Belongs to the TAF2 family. SEQUENCE CAUTION: Sequence=AAC68502.1; Type=Erroneous initiation; Sequence=AAH64830.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6P1X5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0001129 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly GO:0003682 chromatin binding GO:0005515 protein binding GO:0043565 sequence-specific DNA binding GO:0044212 transcription regulatory region DNA binding GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly
Biological Process: GO:0000086 G2/M transition of mitotic cell cycle GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0006367 transcription initiation from RNA polymerase II promoter GO:0014070 response to organic cyclic compound GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly GO:1901796 regulation of signal transduction by p53 class mediator
BC037262 - Homo sapiens, clone IMAGE:3924558, mRNA. AL137601 - Homo sapiens mRNA; cDNA DKFZp434E0811 (from clone DKFZp434E0811); partial cds. BC008473 - Homo sapiens, clone IMAGE:4282266, mRNA. BC018010 - Homo sapiens, clone IMAGE:4281881, mRNA. LF385041 - JP 2014500723-A/192544: Polycomb-Associated Non-Coding RNAs. AK001618 - Homo sapiens cDNA FLJ10756 fis, clone NT2RP3004572, highly similar to Homo sapiens TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150 kDa (TAF2), mRNA. AK001909 - Homo sapiens cDNA FLJ11047 fis, clone PLACE1004510, highly similar to Homo sapiens TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150 kDa (TAF2), mRNA. JD287109 - Sequence 268133 from Patent EP1572962. JD110215 - Sequence 91239 from Patent EP1572962. LF336623 - JP 2014500723-A/144126: Polycomb-Associated Non-Coding RNAs. JD120676 - Sequence 101700 from Patent EP1572962. JD285054 - Sequence 266078 from Patent EP1572962. JD285053 - Sequence 266077 from Patent EP1572962. JD300193 - Sequence 281217 from Patent EP1572962. JD390235 - Sequence 371259 from Patent EP1572962. JD516121 - Sequence 497145 from Patent EP1572962. JD050250 - Sequence 31274 from Patent EP1572962. JD297235 - Sequence 278259 from Patent EP1572962. AF040701 - Homo sapiens TATA binding protein associated factor (TAFII150) mRNA, complete cds. AF026445 - Homo sapiens cofactor of initiator function (CIF150) mRNA, complete cds. JD502774 - Sequence 483798 from Patent EP1572962. JD043263 - Sequence 24287 from Patent EP1572962. AF057694 - Homo sapiens TBP-associated factor TAFII150 (TAFII150) mRNA, complete cds. AK316592 - Homo sapiens cDNA, FLJ95940, highly similar to Homo sapiens TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa (TAF2), mRNA. BC146379 - Synthetic construct Homo sapiens clone IMAGE:100015121, MGC:180212 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa (TAF2) mRNA, encodes complete protein. LF336624 - JP 2014500723-A/144127: Polycomb-Associated Non-Coding RNAs. LF336630 - JP 2014500723-A/144133: Polycomb-Associated Non-Coding RNAs. BC035673 - Homo sapiens TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa, mRNA (cDNA clone IMAGE:5741328), partial cds. BC047732 - Homo sapiens TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa, mRNA (cDNA clone IMAGE:6470186), partial cds. BC064830 - Homo sapiens TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa, mRNA (cDNA clone IMAGE:6453698), partial cds. LF336641 - JP 2014500723-A/144144: Polycomb-Associated Non-Coding RNAs. JD378147 - Sequence 359171 from Patent EP1572962. JD451974 - Sequence 432998 from Patent EP1572962. JD323109 - Sequence 304133 from Patent EP1572962. JD139190 - Sequence 120214 from Patent EP1572962. JD211325 - Sequence 192349 from Patent EP1572962. MA620618 - JP 2018138019-A/192544: Polycomb-Associated Non-Coding RNAs. MA572200 - JP 2018138019-A/144126: Polycomb-Associated Non-Coding RNAs. MA572201 - JP 2018138019-A/144127: Polycomb-Associated Non-Coding RNAs. MA572207 - JP 2018138019-A/144133: Polycomb-Associated Non-Coding RNAs. MA572218 - JP 2018138019-A/144144: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa03022 - Basal transcription factors
Reactome (by CSHL, EBI, and GO)
Protein Q6P1X5 (Reactome details) participates in the following event(s):
R-HSA-109636 Recognition and Binding of Core Promoter Elements by TFIID R-HSA-73946 Abortive initiation R-HSA-75856 Abortive Initiation Before Second Transition R-HSA-75873 Addition of Nucleotides 5 through 9 on the growing Transcript R-HSA-167136 Addition of nucleotides 5 through 9 on the growing HIV-1 transcript R-HSA-167474 Abortive HIV-1 Initiation Before Second Transition R-HSA-167477 Abortive HIV-1 initiation after formation of the first phosphodiester bond R-HSA-75866 Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP R-HSA-75861 NTP Binds Active Site of RNA Polymerase II R-HSA-75864 Newly Formed Phosphodiester Bond Stabilized and PPi Released R-HSA-109637 Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex R-HSA-75862 Fall Back to Closed Pre-initiation Complex R-HSA-75949 RNA Polymerase II Promoter Opening: First Transition R-HSA-167134 Newly formed phosphodiester bond stabilized and PPi released R-HSA-167130 Nucleophillic attack by 3'-hydroxyl oxygen of nascent HIV-1 transcript on the Alpha phosphate of NTP R-HSA-167118 NTP binds active site of RNA Polymerase II in HIV-1 open pre-initiation complex R-HSA-167484 Fall Back to Closed Pre-initiation Complex R-HSA-167097 HIV Promoter Opening: First Transition R-HSA-6805399 TAF1 phosphorylates TP53 R-HSA-109638 Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex R-HSA-75095 Binding of TFIIE to the growing preinitiation complex R-HSA-109639 Formation of the closed pre-initiation complex R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-674695 RNA Polymerase II Pre-transcription Events R-HSA-73776 RNA Polymerase II Promoter Escape R-HSA-167162 RNA Polymerase II HIV Promoter Escape R-HSA-167161 HIV Transcription Initiation R-HSA-75953 RNA Polymerase II Transcription Initiation R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-167172 Transcription of the HIV genome R-HSA-73857 RNA Polymerase II Transcription R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation R-HSA-162599 Late Phase of HIV Life Cycle R-HSA-74160 Gene expression (Transcription) R-HSA-5633007 Regulation of TP53 Activity R-HSA-162587 HIV Life Cycle R-HSA-3700989 Transcriptional Regulation by TP53 R-HSA-162906 HIV Infection R-HSA-212436 Generic Transcription Pathway R-HSA-5663205 Infectious disease R-HSA-1643685 Disease
US Server
