Description: Homo sapiens synovial sarcoma, X breakpoint 2 (SSX2B), transcript variant 1, mRNA. RefSeq Summary (NM_003147): The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. This gene, and also the SSX1 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. This gene also has an identical duplicate, GeneID: 727837, located about 45 kb downstream in the opposite orientation on chromosome X. [provided by RefSeq, Jul 2013]. Transcript (Including UTRs) Position: hg19 chrX:52,780,308-52,790,617 Size: 10,310 Total Exon Count: 9 Strand: + Coding Region Position: hg19 chrX:52,781,758-52,789,480 Size: 7,723 Coding Exon Count: 7
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q16385-2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Descriptions from all associated GenBank mRNAs
BC103863 - Homo sapiens synovial sarcoma, X breakpoint 2, mRNA (cDNA clone MGC:119055 IMAGE:40003337), complete cds. JD378390 - Sequence 359414 from Patent EP1572962. Z49105 - H.sapiens HD21 mRNA. X86175 - H.sapiens mRNA for SSX2 protein. BC016957 - Homo sapiens synovial sarcoma, X breakpoint 2, mRNA (cDNA clone MGC:21532 IMAGE:3916128), complete cds. BC002818 - Homo sapiens synovial sarcoma, X breakpoint 2, mRNA (cDNA clone MGC:3884 IMAGE:3636268), complete cds. BC007343 - Homo sapiens synovial sarcoma, X breakpoint 2, mRNA (cDNA clone MGC:15364 IMAGE:3615133), complete cds. BC071827 - Homo sapiens synovial sarcoma, X breakpoint 2, mRNA (cDNA clone MGC:88485 IMAGE:4641362), complete cds. JD240326 - Sequence 221350 from Patent EP1572962. JD057997 - Sequence 39021 from Patent EP1572962. JD488298 - Sequence 469322 from Patent EP1572962. Z49106 - H.sapiens Mel-40 mRNA for B-cell antigen. KJ892211 - Synthetic construct Homo sapiens clone ccsbBroadEn_01605 SSX2 gene, encodes complete protein. CU675627 - Synthetic construct Homo sapiens gateway clone IMAGE:100017997 5' read SSX2 mRNA. KJ897607 - Synthetic construct Homo sapiens clone ccsbBroadEn_07001 SSX2 gene, encodes complete protein. AB464264 - Synthetic construct DNA, clone: pF1KB8334, Homo sapiens SSX2 gene for synovial sarcoma, X breakpoint 2, without stop codon, in Flexi system. EU446707 - Synthetic construct Homo sapiens clone IMAGE:100070091; IMAGE:100011916; FLH258152.01L synovial sarcoma, X breakpoint 2 (SSX2) gene, encodes complete protein. AM393802 - Synthetic construct Homo sapiens clone IMAGE:100002115 for hypothetical protein (SSX2 gene). BC069313 - Homo sapiens synovial sarcoma, X breakpoint 2, transcript variant 2, mRNA (cDNA clone MGC:96920 IMAGE:7262129), complete cds. JX014236 - Homo sapiens cell-line SKMEL28 SSX2 mRNA, complete cds, alternatively spliced. S79894 - SYT...SSX {translocation breakpoint} [human, synovial sarcoma patient, tumor, mRNA Mutant, 3 genes, 165 nt]. S79332 - SYT...SSX2 {translocation breakpoint} [human, synovial sarcomas, mRNA Partial Mutant, 3 genes, 585 nt]. X79200 - Homo spaiens mRNA for SYT-SSX protein. AF190791 - Homo sapiens SSX2 (SSX2) mRNA, partial cds, alternatively spliced. JD349323 - Sequence 330347 from Patent EP1572962. JD103483 - Sequence 84507 from Patent EP1572962. JD330243 - Sequence 311267 from Patent EP1572962. JD060165 - Sequence 41189 from Patent EP1572962. JD445052 - Sequence 426076 from Patent EP1572962. JD090320 - Sequence 71344 from Patent EP1572962. JD267802 - Sequence 248826 from Patent EP1572962. JD417283 - Sequence 398307 from Patent EP1572962. JD333979 - Sequence 315003 from Patent EP1572962. JD285863 - Sequence 266887 from Patent EP1572962. JD411575 - Sequence 392599 from Patent EP1572962. JD050238 - Sequence 31262 from Patent EP1572962. JD053702 - Sequence 34726 from Patent EP1572962. JD293037 - Sequence 274061 from Patent EP1572962. JD426958 - Sequence 407982 from Patent EP1572962. JD188073 - Sequence 169097 from Patent EP1572962.