Description: Homo sapiens polybromo 1 (PBRM1), mRNA. RefSeq Summary (NM_018313): This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. The encoded protein has been identified as in integral component of complexes necessary for ligand-dependent transcriptional activation by nuclear hormone receptors. Mutations at this locus have been associated with primary clear cell renal cell carcinoma. [provided by RefSeq, Feb 2012]. Transcript (Including UTRs) Position: hg19 chr3:52,579,368-52,713,739 Size: 134,372 Total Exon Count: 28 Strand: - Coding Region Position: hg19 chr3:52,582,079-52,713,727 Size: 131,649 Coding Exon Count: 28
Adiponectin Zari Dastani et al. PLoS genetics 2012, Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals., PLoS genetics.
[PubMed 22479202]
Adiponectin Zari Dastani et al. PLoS genetics 2012, Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals., PLoS genetics.
[PubMed 22479202]
major mood disorders: bipolar, major depression McMahon ,et al. Nat Genet 2010, Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1 , Nature genetics 2010 42- 2 : 128-31.
[PubMed 20081856]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q86U86-3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.