Human Gene NOC3L (uc001kjq.1)
  Description: Homo sapiens nucleolar complex associated 3 homolog (S. cerevisiae) (NOC3L), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr10:96,092,989-96,122,683 Size: 29,695 Total Exon Count: 21 Strand: -
Coding Region
   Position: hg19 chr10:96,093,934-96,122,595 Size: 28,662 Coding Exon Count: 21 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:96,092,989-96,122,683)mRNA (may differ from genome)Protein (800 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMGIneXtProt
OMIMPubMedTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: NOC3L_HUMAN
DESCRIPTION: RecName: Full=Nucleolar complex protein 3 homolog; Short=NOC3 protein homolog; AltName: Full=Factor for adipocyte differentiation 24; AltName: Full=NOC3-like protein; AltName: Full=Nucleolar complex-associated protein 3-like protein;
FUNCTION: May be required for adipogenesis (By similarity).
SUBCELLULAR LOCATION: Nucleus, nucleolus. Nucleus speckle.
TISSUE SPECIFICITY: Expressed in colon, heart, kidney, liver, lung, placenta, skeletal muscle, small intestine, spleen and thymus.
SIMILARITY: Belongs to the CBF/MAK21 family.
SEQUENCE CAUTION: Sequence=BAB14291.1; Type=Erroneous initiation; Sequence=BAB15599.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): NOC3L
CDC HuGE Published Literature: NOC3L
Positive Disease Associations: Interleukin-6 , Stroke
Related Studies:
  1. Interleukin-6
    Emelia J Benjamin et al. BMC medical genetics 2007, Genome-wide association with select biomarker traits in the Framingham Heart Study., BMC medical genetics. [PubMed 17903293]
    The Framingham GWAS represents a resource to describe potentially novel genetic influences on systemic biomarker variability. The newly described associations will need to be replicated in other studies.
  2. Stroke
    , , . [PubMed 0]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 14.38 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 182.32 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -19.5288-0.222 Picture PostScript Text
3' UTR -236.67945-0.250 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011989 - ARM-like
IPR005612 - CCAAT-binding_factor
IPR011501 - NOC3p
IPR016903 - Nucleolar_cplx-assoc_3

Pfam Domains:
PF03914 - CBF/Mak21 family
PF07540 - Nucleolar complex-associated protein

SCOP Domains:
48371 - ARM repeat

ModBase Predicted Comparative 3D Structure on Q8WTT2
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserGenome BrowserGenome Browser
Gene Details  Gene DetailsGene DetailsGene Details
Gene Sorter  Gene SorterGene SorterGene Sorter
  EnsemblFlyBaseWormBaseSGD
  Protein SequenceProtein SequenceProtein SequenceProtein Sequence
  AlignmentAlignmentAlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003682 chromatin binding
GO:0003723 RNA binding

Biological Process:
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0045444 fat cell differentiation

Cellular Component:
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005739 mitochondrion
GO:0016607 nuclear speck


-  Descriptions from all associated GenBank mRNAs
  AK302028 - Homo sapiens cDNA FLJ59781 complete cds, highly similar to Nucleolar complex protein 3 homolog.
AK022882 - Homo sapiens cDNA FLJ12820 fis, clone NT2RP2002736.
AK026953 - Homo sapiens cDNA: FLJ23300 fis, clone HEP10984.
BC049850 - Homo sapiens nucleolar complex associated 3 homolog (S. cerevisiae), mRNA (cDNA clone MGC:52005 IMAGE:5549517), complete cds.
JD320481 - Sequence 301505 from Patent EP1572962.
JD435945 - Sequence 416969 from Patent EP1572962.
JD113450 - Sequence 94474 from Patent EP1572962.
AK091246 - Homo sapiens cDNA FLJ33927 fis, clone CTONG2017429.
AX746873 - Sequence 398 from Patent EP1308459.
JD207252 - Sequence 188276 from Patent EP1572962.
JD286354 - Sequence 267378 from Patent EP1572962.
JD042642 - Sequence 23666 from Patent EP1572962.
AK292520 - Homo sapiens cDNA FLJ77615 complete cds, highly similar to Homo sapiens nucleolar complex associated 3 homolog (S. cerevisiae) (NOC3L), mRNA.
JD510033 - Sequence 491057 from Patent EP1572962.
JD280973 - Sequence 261997 from Patent EP1572962.
JD074082 - Sequence 55106 from Patent EP1572962.
AB077992 - Homo sapiens mRNA for AD24, complete cds.
BC030999 - Homo sapiens nucleolar complex associated 3 homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:4722101), with apparent retained intron.
JD357784 - Sequence 338808 from Patent EP1572962.
JD201177 - Sequence 182201 from Patent EP1572962.
DQ594753 - Homo sapiens piRNA piR-60865, complete sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: AD24, C10orf117, FAD24, NM_022451, NOC3L_HUMAN, NP_071896, Q8WTT2, Q9H5M6, Q9H9D8
UCSC ID: uc001kjq.1
RefSeq Accession: NM_022451
Protein: Q8WTT2 (aka NOC3L_HUMAN)
CCDS: CCDS7433.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_022451.9
exon count: 21CDS single in 3' UTR: no RNA size: 3475
ORF size: 2403CDS single in intron: no Alignment % ID: 99.97
txCdsPredict score: 4883.00frame shift in genome: no % Coverage: 98.88
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.