Human Gene TMEM184B (uc003avf.1)
  Description: Homo sapiens transmembrane protein 184B (TMEM184B), transcript variant 2, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr22:38,615,298-38,668,670 Size: 53,373 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg19 chr22:38,617,476-38,643,967 Size: 26,492 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr22:38,615,298-38,668,670)mRNA (may differ from genome)Protein (407 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
H-INVHGNCHPRDLynxMGIneXtProt
PubMedTreefamUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: T184B_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 184B; AltName: Full=Putative MAPK-activating protein FM08;
FUNCTION: May activate the MAP kinase signaling pathway.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Belongs to the TMEM184 family.
SEQUENCE CAUTION: Sequence=BAC11607.1; Type=Erroneous initiation; Sequence=CAB51403.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 38.22 RPKM in Brain - Cortex
Total median expression: 1026.99 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -107.90224-0.482 Picture PostScript Text
3' UTR -960.572178-0.441 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005178 - Ost-alpha

Pfam Domains:
PF03619 - Organic solute transporter Ostalpha

ModBase Predicted Comparative 3D Structure on Q9Y519
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005215 transporter activity

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  KJ893473 - Synthetic construct Homo sapiens clone ccsbBroadEn_02867 TMEM184B gene, encodes complete protein.
LF210363 - JP 2014500723-A/17866: Polycomb-Associated Non-Coding RNAs.
BC015489 - Homo sapiens transmembrane protein 184B, mRNA (cDNA clone MGC:8943 IMAGE:3896682), complete cds.
CR749859 - Homo sapiens mRNA; cDNA DKFZp686F07174 (from clone DKFZp686F07174).
BX648345 - Homo sapiens mRNA; cDNA DKFZp686L03172 (from clone DKFZp686L03172).
AB097053 - Homo sapiens mRNA for putative MAPK activating protein, complete cds, clone: FM08.
AK292652 - Homo sapiens cDNA FLJ75206 complete cds.
AK309071 - Homo sapiens cDNA, FLJ99112.
MA445940 - JP 2018138019-A/17866: Polycomb-Associated Non-Coding RNAs.
AF161374 - Homo sapiens HSPC256 mRNA, partial cds.
AK095109 - Homo sapiens cDNA FLJ37790 fis, clone BRHIP3000111.
AK075417 - Homo sapiens cDNA PSEC0108 fis, clone NT2RP2005670.
AL096879 - Novel human mRNA similar to C. elegans gene WP:CE18674, TR:Q19985.
CR627445 - Homo sapiens mRNA; cDNA DKFZp686N1150 (from clone DKFZp686N1150).
AL117649 - Homo sapiens mRNA; cDNA DKFZp586A1024 (from clone DKFZp586A1024).
BC012983 - Homo sapiens transmembrane protein 184B, mRNA (cDNA clone IMAGE:3627619).
JD367077 - Sequence 348101 from Patent EP1572962.
JD226240 - Sequence 207264 from Patent EP1572962.
JD088066 - Sequence 69090 from Patent EP1572962.
JD149837 - Sequence 130861 from Patent EP1572962.
JD129737 - Sequence 110761 from Patent EP1572962.
JD188575 - Sequence 169599 from Patent EP1572962.
JD118809 - Sequence 99833 from Patent EP1572962.
JD498049 - Sequence 479073 from Patent EP1572962.
JD099298 - Sequence 80322 from Patent EP1572962.
JD353599 - Sequence 334623 from Patent EP1572962.
JD157325 - Sequence 138349 from Patent EP1572962.
JD339115 - Sequence 320139 from Patent EP1572962.
JD473114 - Sequence 454138 from Patent EP1572962.
JD310871 - Sequence 291895 from Patent EP1572962.
JD456462 - Sequence 437486 from Patent EP1572962.
JD368823 - Sequence 349847 from Patent EP1572962.
JD283139 - Sequence 264163 from Patent EP1572962.
JD156629 - Sequence 137653 from Patent EP1572962.
JD497026 - Sequence 478050 from Patent EP1572962.
JD254211 - Sequence 235235 from Patent EP1572962.
JD278950 - Sequence 259974 from Patent EP1572962.
JD426897 - Sequence 407921 from Patent EP1572962.
JD411266 - Sequence 392290 from Patent EP1572962.
JD130264 - Sequence 111288 from Patent EP1572962.
JD426033 - Sequence 407057 from Patent EP1572962.
JD217030 - Sequence 198054 from Patent EP1572962.
JD114806 - Sequence 95830 from Patent EP1572962.
JD389425 - Sequence 370449 from Patent EP1572962.
JD191479 - Sequence 172503 from Patent EP1572962.
JD100617 - Sequence 81641 from Patent EP1572962.
LF337278 - JP 2014500723-A/144781: Polycomb-Associated Non-Coding RNAs.
JD276143 - Sequence 257167 from Patent EP1572962.
JD276264 - Sequence 257288 from Patent EP1572962.
JD377013 - Sequence 358037 from Patent EP1572962.
JD477554 - Sequence 458578 from Patent EP1572962.
JD409939 - Sequence 390963 from Patent EP1572962.
JD228353 - Sequence 209377 from Patent EP1572962.
JD525560 - Sequence 506584 from Patent EP1572962.
JD544222 - Sequence 525246 from Patent EP1572962.
JD521493 - Sequence 502517 from Patent EP1572962.
JD164178 - Sequence 145202 from Patent EP1572962.
JD114807 - Sequence 95831 from Patent EP1572962.
JD451968 - Sequence 432992 from Patent EP1572962.
JD206083 - Sequence 187107 from Patent EP1572962.
JD475745 - Sequence 456769 from Patent EP1572962.
JD527996 - Sequence 509020 from Patent EP1572962.
JD230990 - Sequence 212014 from Patent EP1572962.
JD493260 - Sequence 474284 from Patent EP1572962.
JD086111 - Sequence 67135 from Patent EP1572962.
JD268937 - Sequence 249961 from Patent EP1572962.
JD163700 - Sequence 144724 from Patent EP1572962.
JD313466 - Sequence 294490 from Patent EP1572962.
LF337282 - JP 2014500723-A/144785: Polycomb-Associated Non-Coding RNAs.
JD156244 - Sequence 137268 from Patent EP1572962.
JD104861 - Sequence 85885 from Patent EP1572962.
JD455460 - Sequence 436484 from Patent EP1572962.
JD163345 - Sequence 144369 from Patent EP1572962.
JD244933 - Sequence 225957 from Patent EP1572962.
CR456413 - Homo sapiens C22orf5 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.C22orf5).
JD118844 - Sequence 99868 from Patent EP1572962.
JD075440 - Sequence 56464 from Patent EP1572962.
JD105034 - Sequence 86058 from Patent EP1572962.
JD121885 - Sequence 102909 from Patent EP1572962.
CU012973 - Homo sapiens C22orf5, mRNA (cDNA clone IMAGE:100000135), complete cds, with stop codon, in Gateway system.
AB528255 - Synthetic construct DNA, clone: pF1KE0490, Homo sapiens TMEM184B gene for transmembrane protein 184B, without stop codon, in Flexi system.
CU013261 - Homo sapiens C22orf5, mRNA (cDNA clone IMAGE:100000039), complete cds, without stop codon, in Gateway system.
LF337285 - JP 2014500723-A/144788: Polycomb-Associated Non-Coding RNAs.
CU677311 - Synthetic construct Homo sapiens gateway clone IMAGE:100019267 5' read TMEM184B mRNA.
LF337290 - JP 2014500723-A/144793: Polycomb-Associated Non-Coding RNAs.
LF337292 - JP 2014500723-A/144795: Polycomb-Associated Non-Coding RNAs.
LF337293 - JP 2014500723-A/144796: Polycomb-Associated Non-Coding RNAs.
LF337295 - JP 2014500723-A/144798: Polycomb-Associated Non-Coding RNAs.
LF337296 - JP 2014500723-A/144799: Polycomb-Associated Non-Coding RNAs.
LF337297 - JP 2014500723-A/144800: Polycomb-Associated Non-Coding RNAs.
LF337301 - JP 2014500723-A/144804: Polycomb-Associated Non-Coding RNAs.
LF337303 - JP 2014500723-A/144806: Polycomb-Associated Non-Coding RNAs.
JD190644 - Sequence 171668 from Patent EP1572962.
JD228483 - Sequence 209507 from Patent EP1572962.
LF337306 - JP 2014500723-A/144809: Polycomb-Associated Non-Coding RNAs.
JD121975 - Sequence 102999 from Patent EP1572962.
JD405570 - Sequence 386594 from Patent EP1572962.
JD423937 - Sequence 404961 from Patent EP1572962.
MA572855 - JP 2018138019-A/144781: Polycomb-Associated Non-Coding RNAs.
MA572859 - JP 2018138019-A/144785: Polycomb-Associated Non-Coding RNAs.
MA572862 - JP 2018138019-A/144788: Polycomb-Associated Non-Coding RNAs.
MA572867 - JP 2018138019-A/144793: Polycomb-Associated Non-Coding RNAs.
MA572869 - JP 2018138019-A/144795: Polycomb-Associated Non-Coding RNAs.
MA572870 - JP 2018138019-A/144796: Polycomb-Associated Non-Coding RNAs.
MA572872 - JP 2018138019-A/144798: Polycomb-Associated Non-Coding RNAs.
MA572873 - JP 2018138019-A/144799: Polycomb-Associated Non-Coding RNAs.
MA572874 - JP 2018138019-A/144800: Polycomb-Associated Non-Coding RNAs.
MA572878 - JP 2018138019-A/144804: Polycomb-Associated Non-Coding RNAs.
MA572880 - JP 2018138019-A/144806: Polycomb-Associated Non-Coding RNAs.
MA572883 - JP 2018138019-A/144809: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K9D7, C22orf5, NM_001195071, NP_001182001, PSEC0108, Q63HM8, Q7Z421, Q8NBM5, Q9UGT8, Q9UGT9, Q9UGV5, Q9Y519, T184B_HUMAN
UCSC ID: uc003avf.1
RefSeq Accession: NM_001195071
Protein: Q9Y519 (aka T184B_HUMAN)
CCDS: CCDS13969.2

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001195071.1
exon count: 9CDS single in 3' UTR: no RNA size: 3644
ORF size: 1224CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2573.00frame shift in genome: no % Coverage: 99.51
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.