ID:SO4A1_HUMAN DESCRIPTION: RecName: Full=Solute carrier organic anion transporter family member 4A1; Short=OATP4A1; AltName: Full=Colon organic anion transporter; AltName: Full=Organic anion transporter polypeptide-related protein 1; Short=OATP-RP1; Short=OATPRP1; Short=POAT; AltName: Full=Organic anion-transporting polypeptide E; Short=OATP-E; AltName: Full=Sodium-independent organic anion transporter E; AltName: Full=Solute carrier family 21 member 12; FUNCTION: Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Ubiquitous, with the exception of spleen and leukocytes. SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family. SIMILARITY: Contains 1 Kazal-like domain. SEQUENCE CAUTION: Sequence=BAA91247.1; Type=Erroneous initiation;
Amyotrophic Lateral Sclerosis Jennifer C Schymick et al. Lancet neurology 2007, Genome-wide genotyping in amyotrophic lateral sclerosis and neurologically normal controls: first stage analysis and public release of data., Lancet neurology.
[PubMed 17362836]
We generated publicly available genotype data for sporadic ALS patients and controls. No single locus was definitively associated with increased risk of developing disease, although potentially associated candidate SNPs were identified.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96BD0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006811 ion transport GO:0043252 sodium-independent organic anion transport GO:0055085 transmembrane transport GO:0070327 thyroid hormone transport
LF206060 - JP 2014500723-A/13563: Polycomb-Associated Non-Coding RNAs. BC015727 - Homo sapiens solute carrier organic anion transporter family, member 4A1, mRNA (cDNA clone MGC:22943 IMAGE:4908245), complete cds. AK023410 - Homo sapiens cDNA FLJ13348 fis, clone OVARC1002127, weakly similar to SODIUM-INDEPENDENT ORGANIC ANION TRANSPORTER 2. AF205072 - Homo sapiens organic anion transporter polypeptide-related protein 1 (OATPRP1) mRNA, complete cds. AF104334 - Homo sapiens putative organic anion transporter mRNA, complete cds. JD319196 - Sequence 300220 from Patent EP1572962. AB031051 - Homo sapiens mRNA for organic anion transporter OATP-E, complete cds. JD331532 - Sequence 312556 from Patent EP1572962. JD367837 - Sequence 348861 from Patent EP1572962. JD196530 - Sequence 177554 from Patent EP1572962. JD154993 - Sequence 136017 from Patent EP1572962. JD446305 - Sequence 427329 from Patent EP1572962. CU677405 - Synthetic construct Homo sapiens gateway clone IMAGE:100020039 5' read SLCO4A1 mRNA. DQ892857 - Synthetic construct clone IMAGE:100005487; FLH190345.01X; RZPDo839H0375D solute carrier organic anion transporter family, member 4A1 (SLCO4A1) gene, encodes complete protein. DQ896104 - Synthetic construct Homo sapiens clone IMAGE:100010564; FLH190341.01L; RZPDo839H0365D solute carrier organic anion transporter family, member 4A1 (SLCO4A1) gene, encodes complete protein. AF187817 - Homo sapiens colon organic anion transporter mRNA, complete cds. KJ898696 - Synthetic construct Homo sapiens clone ccsbBroadEn_08090 SLCO4A1 gene, encodes complete protein. JD021984 - Sequence 3008 from Patent EP1572962. JD033797 - Sequence 14821 from Patent EP1572962. AK000551 - Homo sapiens cDNA FLJ20544 fis, clone KAT11437. AK095985 - Homo sapiens cDNA FLJ38666 fis, clone HLUNG2004416. JD371450 - Sequence 352474 from Patent EP1572962. JD414272 - Sequence 395296 from Patent EP1572962. JD304039 - Sequence 285063 from Patent EP1572962. JD252213 - Sequence 233237 from Patent EP1572962. MA441637 - JP 2018138019-A/13563: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q96BD0 (Reactome details) participates in the following event(s):
R-HSA-879575 SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol R-HSA-879518 Transport of organic anions R-HSA-425397 Transport of vitamins, nucleosides, and related molecules R-HSA-425407 SLC-mediated transmembrane transport R-HSA-382551 Transport of small molecules