Description: Homo sapiens zyg-11 related, cell cycle regulator (ZER1), mRNA. RefSeq Summary (NM_006336): This gene encodes a subunit of an E3 ubiquitin ligase complex that may be involved in meiosis. The encoded protein contains three leucine-rich repeat motifs. [provided by RefSeq, Nov 2012]. Transcript (Including UTRs) Position: hg19 chr9:131,492,067-131,534,213 Size: 42,147 Total Exon Count: 16 Strand: - Coding Region Position: hg19 chr9:131,493,616-131,517,844 Size: 24,229 Coding Exon Count: 15
ID:ZER1_HUMAN DESCRIPTION: RecName: Full=Protein zer-1 homolog; AltName: Full=Hzyg; AltName: Full=Zyg-11 homolog B-like protein; FUNCTION: Probably acts as target recruitment subunit in the E3 ubiquitin ligase complex ZER1-CUL2-Elongin BC. SUBUNIT: Interacts with the TCEB1-TCEB2/Elongin BC complex. Part of an E3 ubiquitin ligase complex including ZER1, CUL2 and Elongin BC. TISSUE SPECIFICITY: Expressed in testis, spermatocytes and spermatids (at protein level). Expressed in spermatocytes, spermatids, prostate, skeletal muscle, ovary, small intestine, heart, brain and pancreas. SIMILARITY: Belongs to the zyg-11 family. SIMILARITY: Contains 5 ARM repeats. SIMILARITY: Contains 3 LRR (leucine-rich) repeats. SEQUENCE CAUTION: Sequence=CAI15408.1; Type=Erroneous gene model prediction; Sequence=CAI15409.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 48371 - ARM repeat 52047 - RNI-like 52058 - L domain-like 52075 - Outer arm dynein light chain 1
ModBase Predicted Comparative 3D Structure on Q7Z7L7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
