Description: Homo sapiens DEAD (Asp-Glu-Ala-Asp) box helicase 6 (DDX6), transcript variant 2, mRNA. RefSeq Summary (NM_001257191): This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2012]. Transcript (Including UTRs) Position: hg19 chr11:118,618,473-118,661,657 Size: 43,185 Total Exon Count: 14 Strand: - Coding Region Position: hg19 chr11:118,625,421-118,656,960 Size: 31,540 Coding Exon Count: 12
ID:DDX6_HUMAN DESCRIPTION: RecName: Full=Probable ATP-dependent RNA helicase DDX6; EC=3.6.4.13; AltName: Full=ATP-dependent RNA helicase p54; AltName: Full=DEAD box protein 6; AltName: Full=Oncogene RCK; FUNCTION: In the process of mRNA degradation, may play a role in mRNA decapping. CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate. SUBUNIT: Forms a complex with DCP1A, DCP2, EDC3 and EDC4/HEDLS. Interacts with LIMD1, WTIP and AJUBA. INTERACTION: Q9NPI6:DCP1A; NbExp=4; IntAct=EBI-351257, EBI-374238; Q96F86:EDC3; NbExp=2; IntAct=EBI-351257, EBI-997311; SUBCELLULAR LOCATION: Cytoplasm, P-body. Note=Processing bodies (PB). TISSUE SPECIFICITY: Abundantly expressed in most tissues. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. DISEASE: Note=A chromosomal aberration involving DDX6 may be a cause of hematopoietic tumors such as B-cell lymphomas. Translocation t(11;14)(q23;q32). SIMILARITY: Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily. SIMILARITY: Contains 1 helicase ATP-binding domain. SIMILARITY: Contains 1 helicase C-terminal domain.
To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): DDX6 CDC HuGE Published Literature: DDX6 Positive Disease Associations: Liver Cirrhosis, Biliary Related Studies:
Liver Cirrhosis, Biliary George F Mells et al. Nature genetics 2011, Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis., Nature genetics.
[PubMed 21399635]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P26196
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
