Description: Homo sapiens transcription factor AP-4 (activating enhancer binding protein 4) (TFAP4), mRNA. RefSeq Summary (NM_003223): Transcription factors of the basic helix-loop-helix-zipper (bHLH-ZIP) family contain a basic domain, which is used for DNA binding, and HLH and ZIP domains, which are used for oligomerization. Transcription factor AP4 activates both viral and cellular genes by binding to the symmetrical DNA sequence CAGCTG (Mermod et al., 1988 [PubMed 2833704]; Hu et al., 1990 [PubMed 2123466]).[supplied by OMIM, Jul 2009]. Transcript (Including UTRs) Position: hg19 chr16:4,307,187-4,323,001 Size: 15,815 Total Exon Count: 7 Strand: - Coding Region Position: hg19 chr16:4,308,056-4,322,747 Size: 14,692 Coding Exon Count: 7
ID:TFAP4_HUMAN DESCRIPTION: RecName: Full=Transcription factor AP-4; AltName: Full=Activating enhancer-binding protein 4; AltName: Full=Class C basic helix-loop-helix protein 41; Short=bHLHc41; FUNCTION: Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5'- CAGCTG-3'. SUBUNIT: Efficient DNA binding requires dimerization with another bHLH protein. Homodimer. SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Contains 1 bHLH (basic helix-loop-helix) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q01664
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003677 DNA binding GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0005515 protein binding GO:0042803 protein homodimerization activity GO:0042826 histone deacetylase binding GO:0043565 sequence-specific DNA binding GO:0044212 transcription regulatory region DNA binding GO:0046983 protein dimerization activity GO:0070888 E-box binding GO:0003713 transcription coactivator activity GO:0046982 protein heterodimerization activity
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0008285 negative regulation of cell proliferation GO:0010629 negative regulation of gene expression GO:0043065 positive regulation of apoptotic process GO:0043392 negative regulation of DNA binding GO:0043922 negative regulation by host of viral transcription GO:0043923 positive regulation by host of viral transcription GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045892 negative regulation of transcription, DNA-templated GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0065003 macromolecular complex assembly GO:0071157 negative regulation of cell cycle arrest GO:0071549 cellular response to dexamethasone stimulus GO:1901990 regulation of mitotic cell cycle phase transition GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
