Human Gene XPO7 (uc003xaa.4) Description and Page Index
  Description: Homo sapiens exportin 7 (XPO7), mRNA.
RefSeq Summary (NM_015024): The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-16 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.136472.1, SRR1660803.163220.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000252512.14/ ENSP00000252512.9 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr8:21,777,180-21,864,096 Size: 86,917 Total Exon Count: 28 Strand: +
Coding Region
   Position: hg19 chr8:21,777,282-21,862,599 Size: 85,318 Coding Exon Count: 28 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:21,777,180-21,864,096)mRNA (may differ from genome)Protein (1087 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: XPO7_HUMAN
DESCRIPTION: RecName: Full=Exportin-7; Short=Exp7; AltName: Full=Ran-binding protein 16;
FUNCTION: Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
SUBUNIT: Binds to nucleoporins. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with ARHGAP1 and SFN. Interacts with Ran and cargo proteins in a GTP- dependent manner.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus (Probable). Nucleus, nuclear pore complex (Probable). Note=Shuttles between the nucleus and the cytoplasm (Probable).
TISSUE SPECIFICITY: Strong expression in testis, thyroid and bone marrow, low expression in lung, liver and small intestine, no expression in thymus, and remaining tissues studied have moderate expression. Expressed in red blood cells; overexpressed in red blood cells (cytoplasm) of patients with hereditary non- spherocytic hemolytic anemia of unknown etiology.
SIMILARITY: Belongs to the exportin family.
SIMILARITY: Contains 1 importin N-terminal domain.
SEQUENCE CAUTION: Sequence=BAA34465.1; Type=Erroneous initiation;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): XPO7
CDC HuGE Published Literature: XPO7
Positive Disease Associations: Albumins , Erythrocyte Indices , Myocardial Infarction
Related Studies:
  1. Albumins
    , , . [PubMed 0]
  2. Erythrocyte Indices
    Yoichiro Kamatani et al. Nature genetics 2010, Genome-wide association study of hematological and biochemical traits in a Japanese population., Nature genetics. [PubMed 20139978]
  3. Myocardial Infarction
    , , . [PubMed 0]
           more ... click here to view the complete list

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 27.16 RPKM in Testis
Total median expression: 731.27 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -37.60102-0.369 Picture PostScript Text
3' UTR -465.451497-0.311 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011989 - ARM-like
IPR016024 - ARM-type_fold
IPR001494 - Importin-beta_N

Pfam Domains:
PF03810 - Importin-beta N-terminal domain

SCOP Domains:
48371 - ARM repeat

ModBase Predicted Comparative 3D Structure on Q9UIA9
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserGenome BrowserGenome BrowserNo ortholog
 Gene Details Gene DetailsGene Details 
 Gene Sorter Gene SorterGene Sorter 
 RGDEnsemblFlyBaseWormBase 
 Protein SequenceProtein SequenceProtein SequenceProtein Sequence 
 AlignmentAlignmentAlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005049 nuclear export signal receptor activity
GO:0005515 protein binding
GO:0008536 Ran GTPase binding

Biological Process:
GO:0006611 protein export from nucleus
GO:0006886 intracellular protein transport
GO:0015031 protein transport
GO:0051028 mRNA transport

Cellular Component:
GO:0005634 nucleus
GO:0005643 nuclear pore
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  BC030785 - Homo sapiens exportin 7, mRNA (cDNA clone MGC:32968 IMAGE:5269230), complete cds.
AK291472 - Homo sapiens cDNA FLJ76855 complete cds, highly similar to Homo sapiens exportin 7 (XPO7), mRNA.
AB018288 - Homo sapiens mRNA for KIAA0745 protein, partial cds.
AF064729 - Homo sapiens RAN binding protein 16 mRNA, complete cds.
CU689010 - Synthetic construct Homo sapiens gateway clone IMAGE:100020481 5' read XPO7 mRNA.
AB383974 - Synthetic construct DNA, clone: pF1KSDA0745, Homo sapiens XPO7 gene for exportin-7, complete cds, without stop codon, in Flexi system.
KJ898438 - Synthetic construct Homo sapiens clone ccsbBroadEn_07832 XPO7 gene, encodes complete protein.
AK311616 - Homo sapiens cDNA, FLJ18658.
AK299848 - Homo sapiens cDNA FLJ56596 complete cds, highly similar to Exportin-7.
BC014219 - Homo sapiens exportin 7, mRNA (cDNA clone IMAGE:3946839), partial cds.
JD155709 - Sequence 136733 from Patent EP1572962.
DQ598350 - Homo sapiens piRNA piR-36416, complete sequence.
JD068430 - Sequence 49454 from Patent EP1572962.
JD196310 - Sequence 177334 from Patent EP1572962.
JD184866 - Sequence 165890 from Patent EP1572962.
JD544257 - Sequence 525281 from Patent EP1572962.
JD045766 - Sequence 26790 from Patent EP1572962.
JD059306 - Sequence 40330 from Patent EP1572962.
JD420821 - Sequence 401845 from Patent EP1572962.
JD266191 - Sequence 247215 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: KIAA0745, NM_015024, NP_055839, O94846, Q6PJK9, Q8NEK7, Q9UIA9, RANBP16, XPO7_HUMAN
UCSC ID: uc003xaa.4
RefSeq Accession: NM_015024
Protein: Q9UIA9 (aka XPO7_HUMAN)
CCDS: CCDS47818.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_015024.4
exon count: 28CDS single in 3' UTR: no RNA size: 4880
ORF size: 3264CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 6434.00frame shift in genome: no % Coverage: 99.65
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 1
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.