Human Gene UBE2K (uc003guu.4) Description and Page Index
Description: Homo sapiens ubiquitin-conjugating enzyme E2K (UBE2K), transcript variant 1, mRNA. RefSeq Summary (NM_005339): The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr4:39,699,664-39,784,410 Size: 84,747 Total Exon Count: 7 Strand: + Coding Region Position: hg19 chr4:39,699,948-39,780,054 Size: 80,107 Coding Exon Count: 7
ID:UBE2K_HUMAN DESCRIPTION: RecName: Full=Ubiquitin-conjugating enzyme E2 K; EC=126.96.36.199; AltName: Full=Huntingtin-interacting protein 2; Short=HIP-2; AltName: Full=Ubiquitin carrier protein; AltName: Full=Ubiquitin-conjugating enzyme E2-25 kDa; Short=Ubiquitin-conjugating enzyme E2(25K); Short=Ubiquitin-conjugating enzyme E2-25K; AltName: Full=Ubiquitin-protein ligase; FUNCTION: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein- dependent degradation of RB1. CATALYTIC ACTIVITY: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Interacts with RNF138/NARF. Interacts with BRCA1. SUBCELLULAR LOCATION: Cytoplasm (By similarity). TISSUE SPECIFICITY: Expressed in all tissues tested, including spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, T-lymphocytes, monocytes, granulocytes and bone marrow mononuclear cells. Highly expressed in brain, with highest levels found in cortex and striatum and at lower levels in cerebellum and brainstem. INDUCTION: By aggregated low-density lipoprotein. PTM: Sumoylation at Lys-14 impairs catalytic activity (By similarity). SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family. SIMILARITY: Contains 1 UBA domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P61086
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006511 ubiquitin-dependent protein catabolic process GO:0010800 positive regulation of peptidyl-threonine phosphorylation GO:0010994 free ubiquitin chain polymerization GO:0016567 protein ubiquitination GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0035458 cellular response to interferon-beta GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0060340 positive regulation of type I interferon-mediated signaling pathway GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070936 protein K48-linked ubiquitination